ArticleNeuroImage2012
Development of BOLD signal hemodynamic responses in the human brain.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
132 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine Learning and Prediction in Fetal, Infant, and Toddler Neuroimaging: A Review and Primer.Biological psychiatry · 2023Pooled it
- Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK.The Lancet. Child & adolescent health · 2024Trial
- The cortical scene processing network emerges in infancy, prior to independent navigation experience.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Characterizing developmental changes in infant habituation using functional change point detection.Neurophotonics · 2026Article
- The longitudinal development of intrinsic timescales in infancy and their relation to alpha brain rhythm.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Face perception and impact of face masks at 6 months post-term age in preterm and term infants (The BabyFace Study).Scientific reports · 2026Article
- The Development of Hippocampal-Cortical Functional Connectivity in Infants and Toddlers.Human brain mapping · 2026Article
- Infants have rich visual categories in ventrotemporal cortex at 2 months of age.Nature neuroscience · 2026Article
- Aperiodic parameters of the fMRI power spectrum associate with preterm birth and neonatal age.Communications biology · 2026Article
- Temporal and Spatial Scales of Human Resting-State Cortical Activity across the Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Precision functional neuroimaging reveals individually specific auditory responses in infants.Developmental cognitive neuroscience · 2026Article
- Shape of the hemodynamic response function in deaf infants eligible for cochlear implantation.Neurophotonics · 2026Article
- Investigating the effect of channel pruning on functional near-infrared spectroscopy data collected from children aged 5 to 24 months.Neurophotonics · 2026Article
- 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development.bioRxiv : the preprint server for biology · 2025Article
- Precision Functional Neuroimaging Reveals Individually Specific Auditory Responses in Infants.bioRxiv : the preprint server for biology · 2025Article
- Measuring neurodevelopment of inhibitory control in children using naturalistic virtual reality.Scientific reports · 2025Article
- Altered cerebral oxygen extraction and metabolism in preterm neonates and the relationship to anemia: A noncontrast MRI study.Annals of the Child Neurology Society · 2024Article
- Neonatal neural responses to novelty related to behavioral inhibition at 1 year.Developmental psychology · 2024Article
- Functional connectivity of the pediatric brain.Neuroradiology · 2024Review
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
In the rodent brain the hemodynamic response to a brief external stimulus changes significantly during development. Analogous changes in human infants would complicate the determination and use of the hemodynamic response function (HRF) for functional magnetic resonance imaging (fMRI) in developing populations. We aimed to characterize HRF in human infants before and after the normal time of birth using rapid sampling of the blood oxygen level dependent (BOLD) signal. A somatosensory stimulus and an event related experimental design were used to collect data from 10 healthy adults, 15 sedated infants at term corrected post menstrual age (PMA) (median 41+1 weeks), and 10 preterm infants (median PMA 34+4 weeks). A positive amplitude HRF waveform was identified across all subject groups, with a systematic maturational trend in terms of decreasing time-to-peak and increasing positive peak amplitude associated with increasing age. Application of the age-appropriate HRF models to fMRI data significantly improved the precision of the fMRI analysis. These findings support the notion of a structured development in the brain's response to stimuli across the last trimester of gestation and beyond.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.