ArticleJournal of translational medicine2012
Metabolomic profiling in blood from umbilical cords of low birth weight newborns.
Article in Journal of translational medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review.Nature communications · 2024Pooled it
- Trial
- An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk.Cell reports. Medicine · 2026Article
- Umbilical cord serum metabolomics identifies amino acid alterations associated with impaired linear growth in small for gestational age infants.Scientific reports · 2025Article
- Impact of maternal anemia during pregnancy on neonatal metabolic profiles: evidence from the Beijing Birth Cohort Study.BMC pregnancy and childbirth · 2025Observational
- Disrupted fetal carbohydrate metabolism in children with autism spectrum disorder.Journal of neurodevelopmental disorders · 2025Article
- [Analysis of the relationship between neonatal birth weight and meconium metabolites based on birth cohort metabolomics].Se pu = Chinese journal of chromatography · 2024Article
- Relationship between one-carbon metabolism and fetal growth in twins: A cohort study.Food science & nutrition · 2023Article
- Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures.Pediatric research · 2023Article
- Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Placental Metabolomics of Fetal Growth Restriction.Metabolites · 2023Article
- Birth weight is associated with obesity and T2DM in adulthood among Chinese women.BMC endocrine disorders · 2022Article
- Association of Maternal Diet during Pregnancy and Metabolite Profile in Cord Blood.Biomolecules · 2022Article
- The Exploration of Fetal Growth Restriction Based on Metabolomics: A Systematic Review.Metabolites · 2022Review
- Differences between Arterial and Venous Umbilical Cord Plasma Metabolome and Association with Parity.Metabolites · 2022Article
- Associations of maternal and infant metabolite profiles with foetal growth and the odds of adverse birth outcomes.Pediatric obesity · 2022Article
- Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity.Metabolites · 2021Article
- Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction.Scientific reports · 2021Article
- Cord serum metabolome and birth weight in patients with gestational diabetes treated with metformin, insulin, or diet alone.BMJ open diabetes research & care · 2021Article
- Prepregnant Obesity of Mothers in a Multiethnic Cohort Is Associated with Cord Blood Metabolomic Changes in Offspring.Journal of proteome research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLow birth weight has been linked to an increased risk to develop obesity, type 2 diabetes, and hypertension in adult life, although the mechanisms underlying the association are not well understood. The objective was to determine whether the metabolomic profile of plasma from umbilical cord differs between low and normal birth weight newborns.
methodsFifty healthy pregnant women and their infants were selected. The eligibility criteria were being born at term and having a normal pregnancy. Pairs were grouped according to their birth weight: low birth weight (LBW, birth weight < 10th percentile, n = 20) and control (control, birth weight between the 75th-90th percentiles, n = 30). Nuclear Magnetic Resonance (NMR) was used to generate metabolic fingerprints of umbilical cord plasma samples. Simultaneously, the metabolomic profiles of the mothers were analysed. The resulting data were subjected to chemometric, principal component and partial least squares discriminant analyses.
resultsUmbilical cord plasma from LBW and control newborns displayed a clearly differentiated metabolic profile. Seven metabolites were identified that discriminate the LBW from the control group. LBW newborns had lower levels of choline, proline, glutamine, alanine and glucose than did the control newborns, while plasma levels of phenylalanine and citrulline were higher in LBW newborns (p < 0.05). No significant differences were found between the two groups of mothers.
conclusionsLow birth weight newborns display a differential metabolomic profile than those of normal birth weight, a finding not present in the mothers. The meaning and the potential utility of the findings as biomarkers of risk need to be addressed in future studies.
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