Evidence map›Paper›PMID 22776268›Full record

ReviewBrain, behavior, and immunity2013

Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications.

Julienne E Bower, Donald M Lamkin

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain, behavior, and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 196 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 11 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05067777 phase2terminatednot on this mapstarted 2022, after this paper: background citation

Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2025Enrolled28ConditionsProstate CarcinomaArmsSwedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
NCT05684367 narecruitingnot on this mapstarted 2023, after this paper: background citation

Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors

TypeinterventionalSponsorUniversity of FloridaRan2023 to 2026Enrolled24ConditionsFatigue, Breast Cancer, Cancer, Therapy-RelatedArmsCenter-Based Walking Exercise, Home-Based Walking Exercise
3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 11 syntheses or guidelines pooled it, 353 citations in OpenAlex.

  1. Pooled it
  2. Machine Learning Models for Predicting Pain, Fatigue, Depression, Anxiety, and Malnutrition in Cancer Patients: A Systematic Review and Meta-Analysis.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2026
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  5. Influence of melatonin supplementation on cancer-related fatigue: a meta-analysis of randomized controlled trials.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
  6. The association between the gut microbiome and fatigue in individuals living with cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  11. Modifiable factors and cognitive dysfunction in breast cancer survivors: a mixed-method systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
    Pooled it
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  17. Effects of exercise on inflammation in patients receiving chemotherapy: a nationwide NCORP randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Julienne E BowerUCLA Department of Psychology, CA 90095-1563, USA. jbower@ucla.edu
Donald M Lamkin
California Department of Education · US

Funding

Biobehavioral predictors of fatigue in newly-diagnosed breast cancer patientsR01CA160427 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BOWER, JULIENNE E · 2012 to 2016
$3.2M
NCI NIH HHS R01 CA160427
6 · The paper itself

Abstract

Fatigue is one of the most common and distressing side effects of cancer and its treatment, and may persist for years after treatment completion in otherwise healthy survivors. Guided by basic research on neuro-immune interactions, a growing body of research has examined the hypothesis that cancer-related fatigue is driven by activation of the pro-inflammatory cytokine network. In this review, we examine the current state of the evidence linking inflammation and cancer-related fatigue, drawing from recent human research and from experimental animal models probing effects of cancer and cancer treatment on inflammation and fatigue. In addition, we consider two key questions that are currently driving research in this area: what are the neural mechanisms of fatigue, and what are the biological and psychological factors that influence the onset and/or persistence of inflammation and fatigue in cancer patients and survivors? Identification of the mechanisms driving cancer-related fatigue and associated risk factors will facilitate the development of targeted interventions for vulnerable patients.

Indexed as

AnimalsFatigueHumansInflammationNeoplasmsRisk Factors

Identifiers

PMID22776268
PMCPMC3978020
OpenAlexW2155056971

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.