ArticleBreast cancer research : BCR2012
Clonal relatedness between lobular carcinoma in situ and synchronous malignant lesions.
Article in Breast cancer research : BCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intercepting Premalignant, Preinvasive Breast Lesions Through Vaccination.Frontiers in immunology · 2021Pooled it
- Impact of concurrent lobular carcinoma in situ on recurrence outcomes in patients with classic and pleomorphic invasive lobular carcinoma of the breast.Breast cancer research and treatment · 2025Article
- Absence of lobular carcinoma in situ is a poor prognostic marker in invasive lobular carcinoma.European journal of cancer (Oxford, England : 1990) · 2023Article
- Synchronous and metachronous bilateral breast cancer among women with a history of lobular carcinoma in situ.Breast cancer research and treatment · 2022Article
- Lobular carcinoma in situ: diagnostic criteria and molecular correlates.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Review
- Quantitative expression of MMPs 2, 9, 14, and collagen IV in LCIS and paired normal breast tissue.Scientific reports · 2019Article
- Lobular CarcinomasClinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Lobular Carcinoma In Situ.Surgical pathology clinics · 2018Review
- Treatment and survival outcomes of lobular carcinomaOncotarget · 2017Article
- Clonal relationships between lobular carcinoma in situ and other breast malignancies.Breast cancer research : BCR · 2016Article
- Targeted capture massively parallel sequencing analysis of LCIS and invasive lobular cancer: Repertoire of somatic genetic alterations and clonal relationships.Molecular oncology · 2016Article
- Lobular Carcinoma in Situ: A 29-Year Longitudinal Experience Evaluating Clinicopathologic Features and Breast Cancer Risk.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Molecular drivers of lobular carcinoma in situ.Breast cancer research : BCR · 2015Review
- Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden.The Journal of pathology · 2015Article
- Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion.Molecular oncology · 2015Article
- Mutational Profiling Can Establish Clonal or Independent Origin in Synchronous Bilateral Breast and Other Tumors.PloS one · 2015Article
- Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast.Diagnostic pathology · 2014Observational
- The Selection of Treatment Modality for Breast Ductal Carcinoma In Situ: Experience From a Single Institution.Cancer control : journal of the Moffitt Cancer CenterArticle
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10 authors.
Funding
Abstract
introductionLobular carcinoma in situ (LCIS) has been accepted as a marker of risk for the development of invasive breast cancer, yet modern models of breast carcinogenesis include LCIS as a precursor of low-grade carcinomas. We provide evidence favoring a clonal origin for LCIS and synchronous estrogen receptor-positive malignant lesions of the ductal and lobular phenotype.
methodsPatients with prior LCIS undergoing mastectomy were identified preoperatively from 2003 to 2008. Specimens were widely sampled, and frozen blocks were screened for LCIS and co-existing malignant lesions, and were subject to microdissection. Samples from 65 patients were hybridized to the Affymetrix SNP 6.0 array platform. Cases with both an LCIS sample and an associated ductal carcinoma in situ (DCIS) or invasive tumor sample were evaluated for patterns of somatic copy number changes to assess evidence of clonal relatedness.
resultsLCIS was identified in 44 of the cases, and among these a DCIS and/or invasive lesion was also identified in 21 cases. A total of 17 tumor pairs had adequate DNA/array data for analysis, including nine pairs of LCIS/invasive lobular cancer, four pairs of LCIS/DCIS, and four pairs of LCIS/invasive ductal cancer. Overall, seven pairs (41%) were judged to be clonally related; in five (29%) evidence suggested clonality but was equivocal, and five (29%) were considered independent. Clonal pairs were observed with all matched lesion types and low and high histological grades. We also show anecdotal evidence of clonality between a patient-matched triplet of LCIS, DCIS, and invasive ductal cancer.
conclusionOur results support the role of LCIS as a precursor in the development of both high-grade and low-grade ductal and lobular cancers.
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