ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2012
Voluntary ingestion of antiparasitic drugs emulsified in honey represents an alternative to gavage in mice.
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- Comparison of Gelatin Flavors for Oral Dosing of C57BL/6J and FVB/N Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice.Clinical epigenetics · 2021Article
- Analysis of Animal Well-Being When Supplementing Drinking Water with Tramadol or Metamizole during Chronic Pancreatitis.Animals : an open access journal from MDPI · 2020Article
- Subacute cannabidiol alters genome-wide DNA methylation in adult mouse hippocampus.Environmental and molecular mutagenesis · 2020Article
- Refining drug administration in a murine model of acute infection withLaboratory animal research · 2020Article
- The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis.Food and waterborne parasitology · 2019Article
- Institutional protocols for the oral administration (gavage) of chemicals and microscopic microbial communities to mice: Analytical consensus.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL.PloS one · 2019Article
- Behavioral toxicity of sodium cyanide following oral ingestion in rats: Dose-dependent onset, severity, survival, and recovery.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Effect ofExperimental and therapeutic medicine · 2018Article
- Behavioral intoxication following voluntary oral ingestion of tetramethylenedisulfotetramine: Dose-dependent onset, severity, survival, and recovery.Neurotoxicology · 2017Article
- Voluntary Oral Administration of Losartan in Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes.PLoS neglected tropical diseases · 2014Article
- Treatment of echinococcosis: albendazole and mebendazole--what else?Parasite (Paris, France) · 2014Review
- Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy.PloS one · 2014Article
- In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes.Antimicrobial agents and chemotherapy · 2013Article
- Subcutaneous infection model facilitates treatment assessment of secondary Alveolar echinococcosis in mice.PLoS neglected tropical diseases · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral route is the most frequently used method of drug intake in humans. Oral administration of drugs to laboratory animals such as mice typically is achieved through gavage, in which a feeding needle is introduced into the esophagus and the drug is delivered directly into the stomach. This method requires technical skill, is stressful for animals, and introduces risk of injury, pain and morbidity. Here we investigated another method of drug administration. The benzimidazole derivative albendazole was emulsified in commercially available honey and administered to mice by voluntary feeding or gavage. Mice that received albendazole by either gavage or honey ingestion had virtually identical levels of serum albendazole sulfoxide, indicating that uptake and metabolism of albendazole was similar for both administration techniques. In addition, dosing mice with the albendazole-honey mixture for 8 wk had antiparasitic activity comparable to earlier studies using gavage for drug administration. Compared with gavage, voluntary ingestion of a drug in honey is more rapid, less stressful to the animal, and less technically demanding for the administrator. Because of its low cost and ready availability, honey presents a viable vehicle for drug delivery.
Indexed as
Identifiers
22776122PMC3314525W2280023184What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.