ArticleEnvironmental health : a global access science source2012
Environmental exposure to arsenic may reduce human semen quality: associations derived from a Chinese cross-sectional study.
Article in Environmental health : a global access science source, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 84 citations in OpenAlex.
- Update of the risk assessment of inorganic arsenic in food.EFSA journal. European Food Safety Authority · 2024Article
- Lifestyle, Insulin Resistance and Semen Quality as Co-Dependent Factors of Male Infertility.International journal of environmental research and public health · 2022Review
- Review
- Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure.Scientific reports · 2021Article
- Transepithelial transport across the blood-testis barrier.Reproduction (Cambridge, England) · 2018Review
- Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats.BioMed research international · 2017Article
- Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity.Scientific reports · 2016Article
- Arsenic and smokeless tobacco induce genotoxicity, sperm abnormality as well as oxidative stress in mice in vivo.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2016Article
- Sex-specific patterns and deregulation of endocrine pathways in the gene expression profiles of Bangladeshi adults exposed to arsenic contaminated drinking water.Toxicology and applied pharmacology · 2015Article
- Air pollution and quality of sperm: a meta-analysis.Iranian Red Crescent medical journal · 2015Review
- Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice.Biomedical and environmental sciences : BES · 2015Article
- Role of low exposure to metals as male reproductive toxicants.International journal of environmental health research · 2015Article
- Urinary metabolomics revealed arsenic internal dose-related metabolic alterations: a proof-of-concept study in a Chinese male cohort.Environmental science & technology · 2014Article
- Maternal arsenic exposure and birth outcomes: a comprehensive review of the epidemiologic literature focused on drinking water.International journal of hygiene and environmental health · 2014Review
- Targeting testis-specific proteins to inhibit spermatogenesis: lesson from endocrine disrupting chemicals.Expert opinion on therapeutic targets · 2013Review
- A comparative evaluation of semen parameters in pre- and post-Hurricane Katrina human population.Asian journal of andrologyArticle
- Exploring the Association between Arsenic Exposure and Sperm Quality: A Systematic Review and Meta-analysis.Journal of human reproductive sciencesReview
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Authors and funding
11 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent observations in in vitro and in vivo models suggest that arsenic (As) is an endocrine disruptor at environmentally-relevant levels. When exposed to As, male rats and mice show steroidogenic dysfunction that can lead to infertility. However, the possible effects of As on human male semen quality remain obscure.
methodsWe monitored the profile of As species in the urine of a reproductive-age human cohort and assessed its association with semen quality. Men (n = 96) were recruited in an infertility clinic from July 2009 to August 2010 in the Affiliated Hospital of Chongqing Institute for Population and Family Planning. Five urinary As species were analyzed by high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (HPLC-ICP-MS). Clinical information on the semen volume, sperm concentration and motility was employed to catalogue and evaluate semen quality according to WHO guidelines. As species concentrations in addition to other continuous variables were dichotomized by the medians and modelled as categorical variables in order to explore using the binary logistic regression possible associations between As exposure and semen quality.
resultsUrinary concentrations (geometric mean ± SD, μg g(-1) creatinine) of different As species were 7.49 (± 24.8) for AsB, 20.9 (± 13.7) for DMA, 2.77 (± 3.33) for MMA, and 4.03 (± 3.67) for Asi (Asi(III )and Asi(V)). DMA concentrations above the median were significantly associated with below-reference sperm concentrations (P = 0.02) after adjusting for age, body mass index (BMI), abstinence, smoking and drinking habits. In addition, smoking was positively associated with MMA.
conclusionReduced parameters in human semen quality are positively associated with As exposure in a reproductive-age Chinese cohort.
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