ArticleComparative medicine2012
Ulcerative dermatitis in C57BL/6 mice exhibits an oxidative stress response consistent with normal wound healing.
Article in Comparative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Systematic Literature Review of Risk Factors and Treatments for Ulcerative Dermatitis in C57BL/6 Mice.Comparative medicine · 2015Pooled it
- Phenotypical, Behavioral, and Systemic Hallmarks in End-Point Mouse Scenarios.Animals : an open access journal from MDPI · 2025Article
- TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFα.Immunity & ageing : I & A · 2023Article
- A carcinogenicity study of diphenylarsinic acid in C57BL/6J mice in drinking water for 78 weeks.Journal of toxicologic pathology · 2023Article
- Evaluation of Treatment Options for Ulcerative Dermatitis in the P Rat.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study.Radiation and environmental biophysics · 2020Article
- Article
- Comparison of 3 Topical Treatments against Ulcerative Dermatitis in Mice with a C57BL/6 Background.Comparative medicine · 2016Article
- Ulcerative Dermatitis in C57BL/6NCrl Mice on a Low-Fat or High-Fat Diet With or Without a Mineralized Red-Algae Supplement.Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Epidermal Fatty Acid binding protein promotes skin inflammation induced by high-fat diet.Immunity · 2015Article
- Antioxidant Therapies for Ulcerative Dermatitis: A Potential Model for Skin Picking Disorder.PloS one · 2015Article
- Incidence rates of spontaneous disease in laboratory mice used at a large biomedical research institution.Journal of the American Association for Laboratory Animal Science : JAALAS · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ulcerative dermatitis (UD) is a common syndrome of unknown etiology that results in profound morbidity in C57BL/6 mice and lines on a C57BL/6 background. The lesions are due to severe pruritus-induced self-trauma, progressing from superficial excoriations to deep ulcerations. UD may be behavioral in origin, with ulcerative lesions resulting from self-mutilating behavior in response to unresolved inflammation or compulsion. Alternatively, abnormal oxidative damage may be a mechanism underlying UD. To evaluate whether UD behaves similarly to normal wounds, consistent with a secondary self-inflicted lesion, or is a distinct disorder with abnormal wound response, we evaluated expression levels of genes representing various arms of the oxidative stress response pathway UD-affected and unwounded C57BL/6J mice. No evidence indicated that UD wounds have a defect in the oxidative stress response. Our findings are consistent with an understanding of C57BL/6 UD lesions as typical rather than atypical wounds.
Indexed as
Identifiers
22776048PMC3364703W1500098758What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.