ArticleNeural development2012
Rapid genetic targeting of pial surface neural progenitors and immature neurons by neonatal electroporation.
Article in Neural development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
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- Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin.Nature neuroscience · 2022Article
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- Optimization of interneuron function by direct coupling of cell migration and axonal targeting.Nature neuroscience · 2018Article
- Physiology of Astroglia.Physiological reviews · 2018Review
- Live Imaging of Adult Neural Stem Cells in Rodents.Frontiers in neuroscience · 2016Review
- Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain.Cold Spring Harbor perspectives in biology · 2015Review
- A transposon-mediated system for flexible control of transgene expression in stem and progenitor-derived lineages.Stem cell reports · 2015Article
- Lost highway(s): barriers to postnatal cortical neurogenesis and implications for brain repair.Frontiers in cellular neuroscience · 2015Review
- Astrocyte heterogeneity in the brain: from development to disease.Frontiers in cellular neuroscience · 2015Review
- Neonatal pial surface electroporation.Journal of visualized experiments : JoVE · 2014Article
- Use of lentiviral vectors to deliver and express bicistronic transgenes in developing chicken embryos.Methods (San Diego, Calif.) · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundRecent findings have indicated the presence of a progenitor domain at the marginal zone/layer 1 of the cerebral cortex, and it has been suggested that these progenitors have neurogenic and gliogenic potential. However, their contribution to the histogenesis of the cortex remains poorly understood due to difficulties associated with genetically manipulating these unique cells in a population-specific manner.
resultsWe have adapted the electroporation technique to target pial surface cells for rapid genetic manipulation at postnatal day 2. In vivo data show that most of these cells proliferate and progressively differentiate into both neuronal and glial subtypes. Furthermore, these cells localize to the superficial layers of the optic tectum and cerebral cortex prior to migration away from the surface.
conclusionsWe provide a foundation upon which future studies can begin to elucidate the molecular controls governing neural progenitor fate, migration, differentiation, and contribution to cortical and tectal histogenesis. Furthermore, specific genetic targeting of such neural progenitor populations will likely be of future clinical interest.
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