ArticleDrugs & aging2012
Inappropriate prescribing of proton pump inhibitors in older patients: effects of an educational strategy.
Article in Drugs & aging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of Interventions to Deprescribe Inappropriate Proton Pump Inhibitors in Older Adults.Drugs & aging · 2017Pooled it
- Systematic review and meta-analysis: what is the evidence for oral iron supplementation in treating anaemia in elderly people?Drugs & aging · 2015Pooled it
- Sustained effectiveness of a multifaceted intervention to reduce potentially inappropriate prescribing in older patients in primary care (OPTI-SCRIPT study).Implementation science : IS · 2016Trial
- Deprescribing of proton pump inhibitors in internal medicine in-patients: A retrospective observational study.Exploratory research in clinical and social pharmacy · 2026Article
- Association between proton pump inhibitors and dementia risk: a Mendelian randomization study.Scientific reports · 2024Article
- Approaches to Deprescribing Proton Pump Inhibitors in Clinical Practice: A Systematic Review.Journal of clinical medicine · 2024Review
- Improving the feasibility of deprescribing proton pump inhibitors: GPs' insights on barriers, facilitators, and strategies.Frontiers in pharmacology · 2024Article
- Identification of Drugs Acting as Perpetrators in Common Drug Interactions in a Cohort of Geriatric Patients from Southern Italy and Analysis of the Gene Polymorphisms That Affect Their Interacting Potential.Geriatrics (Basel, Switzerland) · 2023Article
- Characteristics of Pharmacists' Interventions Related to Proton-Pump Inhibitors in French Hospitals: An Observational Study.International journal of clinical practice · 2022Observational
- Using electronic admission data to monitor temporal trends in local medication use: Experience from an Australian tertiary teaching hospital.Frontiers in pharmacology · 2022Article
- Incorporating pharmacokinetic data into personalised prescribing for older people: challenges and opportunities.European geriatric medicine · 2021Review
- The Clinical Impact of Proton Pump Inhibitors When Co-Administered With Dual Antiplatelet Therapy in Patients Having Acute Myocardial Infarction With Low Risk of Gastrointestinal Bleeding: Insights From the China Acute Myocardial Infarction Registry.Frontiers in cardiovascular medicine · 2021Article
- Appropriateness of gastrointestinal prophylaxis use during hospitalization in patients with acute myocardial infarction: Analysis from the China Acute Myocardial Infarction Registry.Clinical cardiology · 2021Observational
- Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study.International journal of environmental research and public health · 2020Article
- Effects of proton pump inhibitor use on risk of Clostridium difficile infection: a hospital cohort study.Journal of gastroenterology · 2019Article
- Predictors of Inappropriate Proton Pump Inhibitors Use in Elderly Patients.Current gerontology and geriatrics research · 2019Article
- Outcomes From a Pharmacist - led Proton Pump Inhibitor Stewardship Program at a Single Institution.Hospital pharmacy · 2018Article
- Association Between Proton Pump Inhibitor Use and Cognitive Function in Women.Gastroenterology · 2017Article
- Long-term use of proton pump inhibitors among community-dwelling persons with and without Alzheimer's disease.European journal of clinical pharmacology · 2017Article
- Human dimethylarginine dimethylaminohydrolase 1 inhibition by proton pump inhibitors and the cardiovascular risk marker asymmetric dimethylarginine: in vitro and in vivo significance.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increasing number of older patients are prescribed proton pump inhibitors (PPIs). However, the extent of inappropriate PPI prescribing in this group is largely unknown.
objectiveWe sought to identify clinical and demographic factors associated with inappropriate PPI prescribing in older patients and to assess the effects of a targeted educational strategy in a controlled hospital environment.
methodsClinical and demographic characteristics and full medication exposure on admission were recorded in 440 consecutive older patients (mean ± SD age 84 ± 7 years) admitted to a teaching hospital between 1 February 2011 and 30 June 2011. A 4-week educational strategy to reduce inappropriate PPI prescribing during hospital stay, either by stopping or reducing PPI doses, was conducted within the study period. The main outcome measures of the study were the incidence of inappropriate PPI prescribing and the effects of interventions to reduce it.
resultsOn admission, PPIs were established therapy in 164 patients (37%). This was considered inappropriate in 100 patients (61%). Lower Charlson Comorbidity Index score (odds ratio [OR] 0.76; 95% CI 0.57, 0.94; p = 0.006) and history of dementia (OR 1.65; 95% CI 1.28, 1.83; p = 0.005) were independently associated with inappropriate PPI prescribing. Interventions to reduce inappropriate PPI prescribing occurred more frequently during and after the education phase (frequency of interventions in patients with inappropriate PPI prescribing: pre-education phase 9%, during education phase 43%, and post-education phase 46%, p = 0.006). Prescribing interventions were not associated with acid rebound symptoms.
conclusionsInappropriate PPI prescribing in older patients is frequent and independently associated with co-morbidities and dementia. A targeted in-hospital educational strategy can significantly and safely reduce inappropriate PPI prescribing in the short term.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.