ArticleJournal of the American Chemical Society2012
A fluorescence light-up Ag nanocluster probe that discriminates single-nucleotide variants by emission color.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Two of a Kind: Composition and Photophysics of Two Silver Nanoclusters Stabilized by the Same DNA Sequence.Journal of the American Chemical Society · 2026Article
- Mechanistic insights into the color transformation of a non-FRET substrate for RNase activity detection.bioRxiv : the preprint server for biology · 2026Article
- Fluorescent nanomaterials for early detection of cancer biomarkers: a review.Mikrochimica acta · 2025Review
- Solid-State Nanopore Analysis of DNA-Templated Silver Nanoclusters: Voltage-Dependent Translocation and Electrolyte Stability.ACS applied materials & interfaces · 2025Article
- An Atom-Precise Understanding of DNA-Stabilized Silver Nanoclusters.Accounts of chemical research · 2024Review
- A non-FRET DNA reporter that changes fluorescence colour upon nuclease digestion.Nature nanotechnology · 2024Article
- Recent Progress in Single-Nucleotide Polymorphism Biosensors.Biosensors · 2023Review
- Interrupted DNA and Slow Silver Cluster Luminescence.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023Article
- Massively Parallel Selection of NanoCluster Beacons.Advanced materials (Deerfield Beach, Fla.) · 2022Article
- Label-free and sensitive MiRNA detection based on turn-on fluorescence of DNA-templated silver nanoclusters coupled with duplex-specific nuclease-assisted signal amplification.Mikrochimica acta · 2021Article
- L-Histidine-DNA interaction: a strategy for the improvement of the fluorescence signal of poly(adenine) DNA-templated gold nanoclusters.Mikrochimica acta · 2021Article
- Structure and luminescence of DNA-templated silver clusters.Nanoscale advances · 2021Review
- Large-scale investigation of the effects of nucleobase sequence on fluorescence excitation and Stokes shifts of DNA-stabilized silver clusters.Nanoscale · 2021Article
- An aptasensor for the label-free detection of thrombin based on turn-on fluorescent DNA-templated Cu/Ag nanoclusters.RSC advances · 2020Article
- Removal of the ARSC advances · 2020Article
- Footprints of Nanoscale DNA-Silver Cluster ChromophoresACS nano · 2019Article
- An aptamer-based fluorometric zearalenone assay using a lighting-up silver nanocluster probe and catalyzed by a hairpin assembly.Mikrochimica acta · 2019Article
- Research advances in the detection of miRNA.Journal of pharmaceutical analysis · 2019Review
- Structural insights into DNA-stabilized silver clusters.Soft matter · 2019Article
- Structural Influence on the Post-Clustering Stability of DNA/AgNCs Fluorescence.Nanomaterials (Basel, Switzerland) · 2019Article
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6 authors.
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Abstract
Rapid and precise screening of small genetic variations, such as single-nucleotide polymorphisms (SNPs), among an individual's genome is still an unmet challenge at point-of-care settings. One crucial step toward this goal is the development of discrimination probes that require no enzymatic reaction and are easy to use. Here we report a new type of fluorescent molecular probe, termed a chameleon NanoCluster Beacon (cNCB), that lights up into different colors upon binding SNP targets. NanoCluster Beacons (NCBs) are collections of a small number of Ag atoms templated on single-stranded DNA that fluoresce strongly when placed in proximity to particular DNA sequences, termed enhancers. Here we show the fluorescence emission color of a NCB can change substantially (a shift of 60-70 nm in the emission maximum) depending upon the alignment between the silver nanocluster and the DNA enhancer sequence. Chameleon NCBs exploit this color shift to directly detect SNPs, based on the fact that different SNPs produce a different alignment between the Ag nanocluster and the enhancer. This SNP detection method has been validated on all single-nucleotide substitution scenarios in three synthetic DNA targets, in six disease-related SNP targets, and in two clinical samples taken from patients with ovarian serous borderline tumors. Samples with single-nucleotide variations can be easily identified by the naked eye under UV excitation, making this method a reliable and low-cost assay with a simple readout format.
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