ArticleJournal of neurochemistry2012
Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons.
Article in Journal of neurochemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Identification of substances which regulate activity of corticotropin-releasing factor-producing neurons in the paraventricular nucleus of the hypothalamus.Scientific reports · 2020Article
- TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.Molecular metabolism · 2018Article
- Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus.Neuroscience · 2017Article
- Frontline Science: Corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology.Journal of leukocyte biology · 2017Article
- Effects of VPAC1 activation in nucleus ambiguus neurons.Brain research · 2017Article
- Parasympathetic Vagal Control of Cardiac Function.Current hypertension reports · 2016Review
- HIV-1-Tat excites cardiac parasympathetic neurons of nucleus ambiguus and triggers prolonged bradycardia in conscious rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Urotensin II promotes vagal-mediated bradycardia by activating cardiac-projecting parasympathetic neurons of nucleus ambiguus.Journal of neurochemistry · 2014Article
- Aldosterone increases cardiac vagal tone via G protein-coupled oestrogen receptor activation.The Journal of physiology · 2013Article
- Nesfatin-1 activates cardiac vagal neurons of nucleus ambiguus and elicits bradycardia in conscious rats.Journal of neurochemistry · 2013Article
- Bradycardic effects mediated by activation of G protein-coupled estrogen receptor in rat nucleus ambiguus.Experimental physiology · 2013Article
- Intracellular endothelin type B receptor-driven Ca2+ signal elicits nitric oxide production in endothelial cells.The Journal of biological chemistry · 2012Article
- Bradycardic effects of microinjections of urocortin 3 into the nucleus ambiguus of the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Urocortin 3 (also known as stresscopin) is an endogenous ligand for the corticotropin-releasing factor receptor 2 (CRF(2)). Despite predominant G(s) coupling of CRF(2), promiscuous coupling with other G proteins has been also associated with the activation of this receptor. As urocortin 3 has been involved in central cardiovascular regulation at hypothalamic and medullary sites, we examined its cellular effects on cardiac vagal neurons of nucleus ambiguus, a key area for the autonomic control of heart rate. Urocortin 3 (1 nM-1000 nM) induced a concentration-dependent increase in cytosolic Ca(2+) concentration that was blocked by the CRF(2) antagonist K41498. In the case of two consecutive treatments with urocortin 3, the second urocortin 3-induced Ca(2+) response was reduced, indicating receptor desensitization. The effect of urocortin 3 was abolished by pre-treatment with pertussis toxin and by inhibition of phospolipase C with U-73122. Urocortin 3 activated Ca(2+) influx via voltage-gated P/Q-type channels as well as Ca(2+) release from endoplasmic reticulum. Urocortin 3 promoted Ca(2+) release via inositol 1,4,5 trisphosphate receptors, but not ryanodine receptors. Our results indicate a novel Ca(2+) -mobilizing effect of urocortin 3 in vagal pre-ganglionic neurons of nucleus ambiguus, providing a cellular mechanism for a previously reported role for this peptide in parasympathetic cardiac regulation.
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