Evidence map›Paper›PMID 22774796›Full record

ArticleAIDS care2013

Mediators of antiretroviral adherence: a multisite international study.

I B Corless, A J Guarino, P K Nicholas, L Tyer-Viola, K Kirksey, J Brion, C Dawson Rose, L S Eller, M Rivero-Mendez, J Kemppainen and 16 more

Abstract readMulticenter Study
In one paragraph

Article in AIDS care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  10. Focus on increasing treatment self-efficacy to improve human immunodeficiency virus treatment adherence.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2012
    Article
  11. Article
  12. Predictors of medication adherence among HIV-positive women in North America.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

I B CorlessSchool of Nursing, MGH Institute of Health Professions, Boston, MA, USA. Icorless@mghihp.edu
A J Guarino
P K Nicholas
L Tyer-Viola
K Kirksey
J Brion
C Dawson Rose
L S Eller
M Rivero-Mendez
J Kemppainen
K Nokes
E Sefcik
J Voss
D Wantland
M O Johnson
J C Phillips
A Webel
S Iipinge
C Portillo
W-T Chen
M Maryland
M J Hamilton
P Reid
D Hickey
W L Holzemer
K M Sullivan

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6M
Case Western Reserve University/Cleveland Clinic CTSA (KL2)KL2RR024990 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$9.5M
HIV/AIDS NURSING CARE AND PREVENTIONT32NR007081 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DAWSON-ROSE, CAROL, VLAHOV, DAVID · 1995 to 2016
$3.8M
Dyadic Processes in the Patient-Provider RelationshipK24MH087220 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSON, MALLORY O · 2009 to 2013
$771k
Functional Health Literacy, Adherence and Symptoms Management among HIV infected R15NR011130 · NINR · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI RIVERO-MENDEZ, MARTA · 2008 to 2008
$225k
NCRR NIH HHS KL2 RR024990NCRR NIH HHS UL1 RR024131NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI027763NIMH NIH HHS K24 MH087220NINR NIH HHS R15 NR011130NINR NIH HHS T32 NR007081
6 · The paper itself

Abstract

The purpose of this study was to investigate the effects of stressful life events (SLE) on medication adherence (3 days, 30 days) as mediated by sense of coherence (SOC), self-compassion (SCS), and engagement with the healthcare provider (eHCP) and whether this differed by international site. Data were obtained from a cross-sectional sample of 2082 HIV positive adults between September 2009 and January 2011 from sites in Canada, China, Namibia, Puerto Rico, Thailand, and US. Statistical tests to explore the effects of stressful life events on antiretroviral medication adherence included descriptive statistics, multivariate analysis of variance, analysis of variance with Bonferroni post-hoc analysis, and path analysis. An examination by international site of the relationships between SLE, SCS, SOC, and eHCP with adherence (3 days and 30 days) indicated these combined variables were related to adherence whether 3 days or 30 days to different degrees at the various sites. SLE, SCS, SOC, and eHCP were significant predictors of adherence past 3 days for the United States (p = < 0.001), Canada (p = 0.006), and Namibia (p = 0.019). The combined independent variables were significant predictors of adherence past 30 days only in the United States and Canada. Engagement with the provider was a significant correlate for antiretroviral adherence in most, but not all, of these countries. Thus, the importance of eHCP cannot be overstated. Nonetheless, our findings need to be accompanied by the caveat that research on variables of interest, while enriched by a sample obtained from international sites, may not have the same relationships in each country.

Indexed as

Life Change EventsProfessional-Patient RelationsAdultAnti-HIV AgentsCanadaChinaCross-Sectional StudiesDrug MonitoringFemaleHIV InfectionsHumansMaleMedication AdherenceMiddle AgedMultivariate AnalysisNamibiaAnti-HIV Agents

Identifiers

PMID22774796
PMCPMC3491166

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.