ArticleInternational journal for parasitology. Drugs and drug resistance2012
Degrees of chloroquine resistance in Plasmodium - is the redox system involved?
Article in International journal for parasitology. Drugs and drug resistance, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Discovery of Sphaeriaurantins as Rapid-Acting Antiplasmodials with Dual Activity in Blood and Liver Stages.Journal of the American Chemical Society · 2026Article
- Protective effect of adenosine triphosphate against hydroxychloroquine ototoxicity in rats.Scientific reports · 2025Article
- Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas.Oncogenesis · 2024Article
- Antiplasmodial peptaibols act through membrane directed mechanisms.Cell chemical biology · 2024Article
- 4-Chlorothymol Exerts Antiplasmodial Activity Impeding Redox Defense System inFrontiers in pharmacology · 2021Article
- Chloroquine and Sulfadoxine-Pyrimethamine Resistance in Sub-Saharan Africa-A Review.Frontiers in genetics · 2021Review
- Mechanisms of artemether toxicity on single cardiomyocytes and protective effect of nanoencapsulation.British journal of pharmacology · 2020Article
- Oxidative Stress, Proton Fluxes, and Chloroquine/Hydroxychloroquine Treatment for COVID-19.Antioxidants (Basel, Switzerland) · 2020Review
- Antimalarial Quinoline Drugs Inhibit β-Hematin and Increase Free Hemin Catalyzing Peroxidative Reactions and Inhibition of Cysteine Proteases.Scientific reports · 2019Article
- Article
- Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity.International journal for parasitology. Drugs and drug resistance · 2018Article
- Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.Scientific reports · 2017Article
- Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum.International journal for parasitology. Drugs and drug resistance · 2017Article
- The putative phospholipase Lip2 counteracts oxidative damage and influences the virulence of Ustilago maydis.Molecular plant pathology · 2017Article
- Article
- Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.PLoS pathogens · 2016Article
- Inhibition of Glutathione Biosynthesis Sensitizes Plasmodium berghei to Antifolates.Antimicrobial agents and chemotherapy · 2016Article
- Role and Regulation of Glutathione Metabolism in Plasmodium falciparum.Molecules (Basel, Switzerland) · 2015Review
- Albendazole induces oxidative stress and DNA damage in the parasitic protozoan Giardia duodenalis.Frontiers in microbiology · 2015Article
- Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Chloroquine (CQ) was once a very effective antimalarial drug that, at its peak, was consumed in the hundreds of millions of doses per year. The drug acts against the Plasmodium parasite during the asexual intraerythrocytic phase of its lifecycle. Unfortunately, clinical resistance to this drug is now widespread. Questions remain about precisely how CQ kills malaria parasites, and by what means some CQ-resistant (CQR) parasites can withstand much higher concentrations of the drug than others that also fall in the CQR category. In this review we investigate the evidence for and against the proposal that CQ kills parasites by generating oxidative stress. Further, we examine a long-held idea that the glutathione system of malaria parasites plays a role in CQ resistance. We conclude that there is strong evidence that glutathione levels modulate CQ response in the rodent malaria species P. berghei, but that a role for redox in contributing to the degree of CQ resistance in species infectious to humans has not been firmly established.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.