ArticleCell reports2012
A motor-driven mechanism for cell-length sensing.
Article in Cell reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
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- Communicating pain: emerging axonal signaling in peripheral neuropathic pain.Frontiers in neuroanatomy · 2024Review
- PTBP1 regulates injury responses and sensory pathways in adult peripheral neurons.Science advances · 2023Article
- A conditional null allele of Dync1h1 enables targeted analyses of dynein roles in neuronal length sensing.Journal of cell science · 2023Article
- Riding the rails - different modes for RNA complex transport in axons.Neural regeneration research · 2022Article
- Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs.Nucleic acids research · 2022Article
- RUFY3 links Arl8b and JIP4-Dynein complex to regulate lysosome size and positioning.Nature communications · 2022Article
- What programs the size of animal cells?Frontiers in cell and developmental biology · 2022Review
- The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization.The EMBO journal · 2021Article
- DYNLRB1 is essential for dynein mediated transport and neuronal survival.Neurobiology of disease · 2020Article
- Developmental regulators FlbE/D orchestrate the polarity site-to-nucleus dynamics of the fungal bZIP transcription factor FlbB.Cellular and molecular life sciences : CMLS · 2019Article
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- hnRNPs Interacting with mRNA Localization Motifs Define Axonal RNA Regulons.Molecular & cellular proteomics : MCP · 2018Article
- A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism.PLoS genetics · 2018Article
- Intrinsic mechanisms of neuronal axon regeneration.Nature reviews. Neuroscience · 2018Review
- Locally translated mTOR controls axonal local translation in nerve injury.Science (New York, N.Y.) · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Size homeostasis is fundamental in cell biology, but it is not clear how large cells such as neurons can assess their own size or length. We examined a role for molecular motors in intracellular length sensing.Computational simulations suggest that spatial information can be encoded by the frequency of an oscillating retrograde signal arising from a composite negative feedback loop between bidirectional motor-dependent signals. The model predicts that decreasing either or both anterograde or retrograde signals should increase cell length, and this prediction was confirmed upon application of siRNAs for specific kinesin and/or dynein heavy chains in adult sensory neurons. Heterozygous dynein heavy chain 1 mutant sensory neurons also exhibited increased lengths both in vitro and during embryonic development.Moreover, similar length increases were observed in mouse embryonic fibroblasts upon partial downregulation of dynein heavy chain 1.Thus, molecular motors critically influence cell length sensing and growth control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.