ArticleBasal ganglia2011
The primate thalamostriatal systems: Anatomical organization, functional roles and possible involvement in Parkinson's disease.
Article in Basal ganglia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Thalamic nuclei volume changes associated with cognitive and motor manifestations of Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Contributions of Basal Ganglia Circuits to Perception, Attention, and Consciousness.Journal of cognitive neuroscience · 2024Review
- Causality methods to study the functional connectivity in brain networks: the basal ganglia - thalamus causal interactions.Brain imaging and behavior · 2024Article
- Micropopulation mapping of the mouse parafascicular nucleus connections reveals diverse input-output motifs.Frontiers in neuroanatomy · 2023Article
- In humans, striato-pallido-thalamic projections are largely segregated by their origin in either the striosome-like or matrix-like compartments.Frontiers in neuroscience · 2023Article
- Disentangling the influences of multiple thalamic nuclei on prefrontal cortex and cognitive control.Neuroscience and biobehavioral reviews · 2021Review
- Comparative analyses of transgene expression patterns after intra-striatal injections of rAAV2-retro in rats and rhesus monkeys: A light and electron microscopic study.The European journal of neuroscience · 2020Article
- Changes in thalamic dopamine innervation in a progressive Parkinson's disease model in monkeys.Movement disorders : official journal of the Movement Disorder Society · 2020Article
- Thalamic degeneration in MPTP-treated Parkinsonian monkeys: impact upon glutamatergic innervation of striatal cholinergic interneurons.Brain structure & function · 2019Article
- The Cognitive Thalamus as a Gateway to Mental Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
- The organization of the basal ganglia functional connectivity network is non-linear in Parkinson's disease.NeuroImage. Clinical · 2019Article
- Which brain lesions produce spasticity? An observational study on 45 stroke patients.PloS one · 2019Observational
- Roles of centromedian parafascicular nuclei of thalamus and cholinergic interneurons in the dorsal striatum in associative learning of environmental events.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Chronic MPTP administration regimen in monkeys: a model of dopaminergic and non-dopaminergic cell loss in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Loss and remodeling of striatal dendritic spines in Parkinson's disease: from homeostasis to maladaptive plasticity?Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Functional Diversity of Thalamic Reticular Subnetworks.Frontiers in systems neuroscience · 2018Article
- Sub-synaptic localization of CaBrain structure & function · 2017Article
- Sensory Processing in the Dorsolateral Striatum: The Contribution of Thalamostriatal Pathways.Frontiers in systems neuroscience · 2017Article
- Basal ganglia and cerebellar interconnectivity within the human thalamus.Brain structure & function · 2017Article
- Intralaminar and tectal projections to the subthalamus in the rat.The European journal of neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The striatum receives glutamatergic inputs from two main thalamostriatal systems that originate either from the centre median/parafascicular complex (CM/PF-striatal system) or the rostral intralaminar, midline, associative and relay thalamic nuclei (non-CM/PF-striatal system). These dual thalamostriatal systems display striking differences in their anatomical and, most likely, functional organization. The CM/PF-striatal system is topographically organized, and integrated within functionally segregated basal ganglia-thalamostriatal circuits that process sensorimotor, associative and limbic information. CM/PF neurons are highly responsive to attention-related sensory stimuli, suggesting that the CM/PF-striatal system, through its strong connections with cholinergic interneurons, may play a role in basal ganglia-mediated learning, behavioral switching and reinforcement. In light of evidence for prominent CM/PF neuronal loss in Parkinson's disease, we propose that the significant CM-striatal system degeneration, combined with the severe nigrostriatal dopamine loss in sensorimotor striatal regions, may alter normal automatic actions, and shift the processing of basal ganglia-thalamocortical motor programs towards goal-directed behaviors.
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Registered trials
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