ArticleInternational journal of biochemistry and molecular biology2012
Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities.
Article in International journal of biochemistry and molecular biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Neuropharmacological effects ofFrontiers in neurology · 2025Review
- Medicinal herbal remedies in neurodegenerative diseases: an update on antioxidant potential.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Protective effect ofBiomedical reports · 2023Article
- Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro.Cell biology and toxicology · 2023Article
- Phytochemical Profiling in Conjunction withACS omega · 2021Article
- Review
- A Review of Herbal Therapy in Multiple Sclerosis.Advanced pharmaceutical bulletin · 2018Review
- Novel Strategies Using Total Gastrodin and Gastrodigenin, or Total Gastrodigenin for Quality Control of Gastrodia elata.Molecules (Basel, Switzerland) · 2018Article
- KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis.Journal of veterinary science · 2017Article
- Bibenzyl compound 20c protects against endoplasmic reticulum stress in tunicamycin-treated PC12 cells in vitro.Acta pharmacologica Sinica · 2016Article
- Gastrodin reversed the traumatic stress-induced depressed-like symptoms in rats.Journal of natural medicines · 2016Article
- Gastrodin Attenuates Cognitive Deficits Induced by 3,3'-Iminodipropionitrile.Neurochemical research · 2016Article
- Prolonged oral administration of Gastrodia elata extract improves spatial learning and memory of scopolamine-treated rats.Laboratory animal research · 2015Article
- Proteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer's Disease.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Recent Advance in Applications of Proteomics Technologies on Traditional Chinese Medicine Research.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Gastrodin ameliorates memory deficits in 3,3'-iminodipropionitrile-induced rats: possible involvement of dopaminergic system.Neurochemical research · 2014Article
- KCHO-1, a Novel Antineuroinflammatory Agent, Inhibits Lipopolysaccharide-Induced Neuroinflammatory Responses through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse BV2 Microglia Cells.Evidence-based complementary and alternative medicine : eCAM · 2014Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tianma (Gastrodia elata Blume) is a traditional Chinese medicine (TCM) often used for the treatment of headache, convulsions, hypertension and neurodegenerative diseases. Tianma also modulates the cleavage of the amyloid precursor protein App and cognitive functions in mice. The neuronal actions of tianma thus led us to investigate its specific effects on neuronal signalling. Accordingly, this pilot study was designed to examine the effects of tianma on the proteome metabolism in differentiated mouse neuronal N2a cells using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach. We identified 2178 proteins, out of which 74 were found to be altered upon tianma treatment in differentiated mouse neuronal N2a cells. Based on the observed data obtained, we hypothesize that tianma could promote neuro-regenerative processes by inhibiting stress-related proteins and mobilizing neuroprotective genes such as Nxn, Dbnl, Mobkl3, Clic4, Mki67 and Bax with various regenerative modalities and capacities related to neuro-synaptic plasticity.
Indexed as
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22773961PMC3388733What OpenQuestion holds
Registered trials
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