ArticleScientific reports2012
T1R3: a human calcium taste receptor.
Article in Scientific reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 81 citations in OpenAlex.
- Sweet and umami TAS1R receptors: from molecular recognition to physiological function.Chemical senses · 2026Review
- Review
- Glutathione as a taste modulator: molecular mechanisms of interaction with umami and sweet taste receptors.Food chemistry. Molecular sciences · 2025Article
- Inosine-5'-monophosphate interacts with the TAS1R3 subunit to enhance sweet taste detection.Food chemistry. Molecular sciences · 2025Article
- Sweet taste receptors play roles in artificial sweetener-induced enhanced urine output in mice.NPJ science of food · 2024Article
- Allosteric modulation of the fish taste receptor type 1 (T1R) family by the extracellular chloride ion.Scientific reports · 2023Article
- The tongue map and the spatial modulation of taste perception.Current research in food science · 2022Review
- What Does the Taste System Tell Us About the Nutritional Composition and Toxicity of Foods?Handbook of experimental pharmacology · 2022Article
- Biophysical and functional characterization of the human TAS1R2 sweet taste receptor overexpressed in a HEK293S inducible cell line.Scientific reports · 2021Article
- Understanding the evolution of nutritive taste in animals: Insights from biological stoichiometry and nutritional geometry.Ecology and evolution · 2021Review
- The umami receptor T1R1-T1R3 heterodimer is rarely formed in chickens.Scientific reports · 2021Article
- Illuminating the allosteric modulation of the calcium-sensing receptor.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- COVID 19-Induced Smell and Taste Impairments: Putative Impact on Physiology.Frontiers in physiology · 2020Review
- Characterizing Dysgeusia in Hemodialysis Patients.Chemical senses · 2019Article
- Taste sensitivity to a mixture of monosodium glutamate and inosine 5'-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- The Different Facets of Extracellular Calcium Sensors: Old and New Concepts in Calcium-Sensing Receptor Signalling and Pharmacology.International journal of molecular sciences · 2018Review
- Calcium Taste Avoidance in Drosophila.Neuron · 2018Article
- Taste buds: cells, signals and synapses.Nature reviews. Neuroscience · 2017Review
- Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction.The Journal of biological chemistry · 2017Article
- Phosphorus Taste Involves T1R2 and T1R3.Chemical senses · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and that this response is attenuated by lactisole, an inhibitor of hT1R3. Moreover, trained volunteers report that lactisole reduces the calcium intensity of calcium lactate. Thus, humans can detect calcium by taste, T1R3 is a receptor responsible for this, and lactisole can reduce the taste perception of calcium by acting on T1R3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.