ArticleVibrational Spectroscopy2012
Attenuated total reflectance Fourier-transform infrared spectroscopic imaging for breast histopathology.
Article in Vibrational Spectroscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 78 citations in OpenAlex.
- Vibrational Biospectroscopy: An Alternative Approach to Endometrial Cancer Diagnosis and Screening.International journal of molecular sciences · 2022Review
- Interrogation ofCancers · 2020Article
- Label-free imaging of lipid-rich biological tissues by mid-infrared photoacoustic microscopy.Journal of biomedical optics · 2020Article
- Quantitative Histopathology of Stained Tissues using Color Spatial Light Interference Microscopy (cSLIM).Scientific reports · 2019Article
- An Innovative Platform Merging Elemental Analysis and Ftir Imaging for Breast Tissue Analysis.Scientific reports · 2019Article
- Standardization of complex biologically derived spectrochemical datasets.Nature protocols · 2019Article
- A comparison of mid-infrared spectral regions on accuracy of tissue classification.The Analyst · 2019Article
- Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks.The Analyst · 2019Article
- Application of Vibrational Spectroscopy and Imaging to Point-of-Care Medicine: A Review.Applied spectroscopy · 2018Review
- Label-free quantitative evaluation of breast tissue using Spatial Light Interference Microscopy (SLIM).Scientific reports · 2018Article
- Infrared spectroscopic imaging: Label-free biochemical analysis of stroma and tissue fibrosis.The international journal of biochemistry & cell biology · 2017Review
- Multi-functionality Redefined with Colloidal Carotene Carbon Nanoparticles for Synchronized Chemical Imaging, Enriched Cellular Uptake and Therapy.Scientific reports · 2016Article
- Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging.Faraday discussions · 2016Article
- Perfluoroalkylated Substance Effects in Xenopus laevis A6 Kidney Epithelial Cells Determined by ATR-FTIR Spectroscopy and Chemometric Analysis.Chemical research in toxicology · 2016Article
- Introducing Discrete Frequency Infrared Technology for High-Throughput Biofluid Screening.Scientific reports · 2016Article
- High-definition Fourier Transform Infrared (FT-IR) spectroscopic imaging of human tissue sections towards improving pathology.Journal of visualized experiments : JoVE · 2015Article
- Using Fourier transform IR spectroscopy to analyze biological materials.Nature protocols · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Histopathology forms the gold standard for the diagnosis of breast cancer. Fourier Transform Infrared (FT-IR) spectroscopic imaging has been proposed to be a potentially powerful adjunct to current histopathological techniques. Most studies using FT-IR imaging for breast tissue analysis have been in the transmission or transmission-reflection mode, in which the wavelength and optics limit the data to a relatively coarse spatial resolution (typically, coarser than 5 μm × 5 μm per pixel). This resolution is insufficient to examine many histologic structures. Attenuated Total Reflectance (ATR) FT-IR imaging incorporating a Germanium optic can allow for a four-fold increase in spatial resolution due to the material's high refractive index in the mid-IR. Here, we employ ATR FT-IR imaging towards examining cellular and tissue structures that constitute and important component of breast cancer diagnosis. In particular, we resolve and chemically characterize endothelial cells, myoepithelial cells and terminal ductal lobular units. Further extending the ability of IR imaging to examine sub-cellular structures, we report the extraction of intact chromosomes from a breast cancer cells and their spatially localized analysis as a novel approach to understand changes associated with the molecular structure of DNA in breast cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.