Evidence map›Paper›PMID 22773822›Full record

ArticleJournal of the National Cancer Institute2012

Initiation of adjuvant hormone therapy by Medicaid insured women with nonmetastatic breast cancer.

Rachel L Yung, Michael J Hassett, Kun Chen, Foster C Gesten, Patrick J Roohan, Francis P Boscoe, Amber H Sinclair, Maria J Schymura, Deborah Schrag

Abstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Racial Differences in Adjuvant Endocrine Therapy Use and Discontinuation in Association with Mortality among Medicare Breast Cancer Patients by Receptor Status.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel L YungDepartment of Medical Oncology, Center for Outcomes and Policy Research, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. ryung1@partners.org.
Michael J Hassett
Kun Chen
Foster C Gesten
Patrick J Roohan
Francis P Boscoe
Amber H Sinclair
Maria J Schymura
Deborah Schrag

Funding

Cancer Care Delivery in MedicaidR01CA131847 · NCI · DANA-FARBER CANCER INST · PI SCHRAG, DEBORAH · 2008 to 2012
$1.8M
Partnerships Between Medicaid, Tumor Registries & Cancer Control ResearchersK05CA169384 · NCI · DANA-FARBER CANCER INST · PI SCHRAG, DEBORAH · 2012 to 2016
$586k
NCI NIH HHS K05 CA169384NCI NIH HHS R01 CA131847NCI NIH HHS R01-CA131847
6 · The paper itself

Abstract

Hormone therapy is the mainstay of adjuvant treatment for hormone receptor positive (HR-positive) nonmetastatic breast cancer. We evaluated adjuvant hormone therapy (AHT) initiation among Medicaid-insured women aged 21-64 years with stage I-III HR-positive breast cancer. We used multivariable logistic regression to identify independent predictors of AHT initiation. Within 1 year of diagnosis, 68% (1049/1538) initiated AHT; by 18 months, 80% (1168/1461) initiated AHT. In multivariable analysis, women less likely to initiate AHT had more comorbidity (≥ 2 vs none: adjusted odds ratio (AOR) = 0.55; 95% CI = 0.32 to 0.97), more advanced disease (stage III vs I: AOR = 0.27; 95% CI = 0.18 to 0.39), and no radiation after breast conserving surgery (AOR = 0.15; 95% CI = 0.10 to 0.22). Race, age, and history of mental health disorders were not independently associated with initiation of AHT. Among initiators of AHT, 58% (604/1049) were adherent to treatment for the year after initiation. Despite comprehensive prescription coverage, only 39% (604/1538) received optimal AHT including prompt initiation and adherence for the year after treatment. Partnerships between Medicaid programs and cancer registries may help identify at-risk women and facilitate the implementation of quality improvement strategies.

Indexed as

BenchmarkingAdultAntineoplastic Agents, HormonalBreast NeoplasmsChemotherapy, AdjuvantDrug Administration ScheduleFemaleHumansLogistic ModelsMedicaidMiddle AgedMultivariate AnalysisNeoplasm StagingOdds RatioUnited StatesAntineoplastic Agents, Hormonal

Identifiers

PMID22773822
PMCPMC3731435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.