ArticleAmerican journal of respiratory and critical care medicine2012
Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.
Article in American journal of respiratory and critical care medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT02975258 (Adiposity and Airway Inflammation in HIV-Associated Airway Disease), which is not on this map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adiposity and Airway Inflammation in HIV-Associated Airway Disease
Who cites it
31 citing papers in PubMed, 71 citations in OpenAlex.
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- Epidemiology of sarcoidosis: current findings and future directions.Therapeutic advances in chronic disease · 2018Review
- Late-onset asthma: current perspectives.Journal of asthma and allergy · 2018Review
- Inflammatory and Oxidative Stress Markers in Experimental Allergic Asthma.Inflammation · 2017Article
- Obesity, Asthma, and Exercise in Child and Adolescent Health.Pediatric exercise science · 2016Article
- Retraction: Alveolar Macrophages from Overweight/Obese Subjects with Asthma Demonstrate a Proinflammatory Phenotype.American journal of respiratory and critical care medicine · 2015Article
- The impact of diet on asthma and allergic diseases.Nature reviews. Immunology · 2015Review
- Article
- Expression of concern: Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype.American journal of respiratory and critical care medicine · 2015Article
- Nutrition and respiratory health--feature review.Nutrients · 2015Review
- Emerging molecular phenotypes of asthma.American journal of physiology. Lung cellular and molecular physiology · 2015Review
- Inflammation, metabolic dysregulation, and pulmonary function among obese urban adolescents with asthma.American journal of respiratory and critical care medicine · 2015Article
- Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma.Journal of allergy · 2015Article
- Asthma and obesity: mechanisms and clinical implications.Asthma research and practice · 2015Review
- Article
- Immunological characteristics and management considerations in obese patients with asthma.Expert review of clinical immunology · 2015Review
- Influence of distinct asthma phenotypes on lung function following weight loss in the obese.Respirology (Carlton, Vic.) · 2014Article
- Obesity and asthma in children: current and future therapeutic options.Paediatric drugs · 2014Review
- Is there a link between obesity and asthma?Allergy, asthma & immunology research · 2014Review
Corrections and comments
- Expression of concern · 2015-04-01Concerns/Issues about Data · Error in Data · Unreliable Results and/or Conclusions · Updated to Retraction ·
- Retraction · 2015-07-15Concerns/Issues about Data · Error in Data · Investigation by Company/Institution · Upgrade/Update of Prior Notice(s) ·
- Commented on by
- Expression of concern
- Retracted
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleObesity is associated with increased prevalence and severity of asthma. Adipose tissue macrophages can contribute to the systemic proinflammatory state associated with obesity. However, it remains unknown whether alveolar macrophages have a unique phenotype in overweight/obese patients with asthma.
objectivesWe hypothesized that leptin levels would be increased in the bronchoalveolar lavage fluid from overweight/obese subjects and, furthermore, that leptin would alter the response of alveolar macrophages to bacterial LPS.
methodsForty-two subjects with asthma and 46 healthy control subjects underwent research bronchoscopy. Bronchoalveolar lavage fluid from 66 was analyzed for the level of cellular inflammation, cytokines, and soluble leptin. Cultured primary macrophages from 22 subjects were exposed to LPS, leptin, or leptin plus LPS. Cytokines were measured in the supernatants. MEASUREMENTS AND MAIN
resultsLeptin levels were increased in overweight/obese subjects, regardless of asthma status (P = 0.013), but were significantly higher in overweight/obese subjects with asthma. Observed levels of tumor necrosis factor-α were highest in overweight/obese subjects with asthma. Ex vivo studies of primary alveolar macrophages indicated that the response to LPS was most robust in alveolar macrophages from overweight/obese subjects with asthma and that preexposure to high-dose leptin enhanced the proinflammatory response. Leptin alone was sufficient to induce production of proinflammatory cytokines from macrophages derived from overweight/obese subjects with asthma.
conclusionsEx vivo studies indicate that alveolar macrophages derived from overweight/obese subjects with asthma are uniquely sensitive to leptin. This macrophage phenotype, in the context of higher levels of soluble leptin, may contribute to the pathogenesis of airway disease associated with obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.