ArticleDiabetes care2012
Antenatal diagnosis of fetal genotype determines if maternal hyperglycemia due to a glucokinase mutation requires treatment.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Continuous Glucose Monitoring in Glucokinase-maturity-onset Diabetes of the Young Pregnancy: A Treatment Paradigm Change.JCEM case reports · 2025Article
- Pregnancy and neonatal outcomes in women with GCK-MODY: an observational study based on standardised insulin modalities.Diabetologia · 2025Observational
- Precision treatment of beta-cell monogenic diabetes: a systematic review.Communications medicine · 2024Article
- Course of pregnancy and 10-year observation of twins diagnosed with GCK-MODY in the neonatal period: a case report.Frontiers in endocrinology · 2024Article
- Management of pregnancy in women with monogenic diabetes due to mutations inFrontiers in genetics · 2024Review
- Bringing precision medicine to the management of pregnancy in women with glucokinase-MODY: a study of diagnostic accuracy and feasibility of non-invasive prenatal testing.Diabetologia · 2023Article
- Systematic Review of Treatment of Beta-Cell Monogenic Diabetes.medRxiv : the preprint server for health sciences · 2023Article
- GCK-MODY in pregnancy: A pregnant woman with diabetes and a small-for-gestational-age fetus.Clinical case reports · 2022Article
- Molecular and clinical assessment of maturity-onset diabetes of the young revealed low mutational rate in Moroccan families.International journal of pediatrics & adolescent medicine · 2022Article
- The Challenges of Treating Glucokinase MODY during Pregnancy: A Review of Maternal and Fetal Outcomes.International journal of environmental research and public health · 2022Review
- Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges.Frontiers in endocrinology · 2021Review
- Uncommon Presentations of Diabetes: Zebras in the Herd.Clinical diabetes : a publication of the American Diabetes Association · 2020Article
- Management and pregnancy outcomes of women with GCK-MODY enrolled in the US Monogenic Diabetes Registry.Acta diabetologica · 2019Observational
- Diagnosis and management of glucokinase monogenic diabetes in pregnancy: current perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Emerging Concepts in Brain Glucose Metabolic Functions: From Glucose Sensing to How the Sweet Taste of Glucose Regulates Its Own Metabolism in Astrocytes and Neurons.Neuromolecular medicine · 2018Review
- Clinical Management of Women with Monogenic Diabetes During Pregnancy.Current diabetes reports · 2018Review
- Monogenic diabetes and pregnancy.Obstetric medicine · 2015Review
- Genetic causes of maturity onset diabetes of the young may be less prevalent in American pregnant women recently diagnosed with diabetes mellitus than in previously studied European populations.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2015Article
- Monogenic glucokinase diabetes and pregnancy: a case study.Wiener klinische Wochenschrift · 2015Article
- Clinical utility gene card for: Maturity-onset diabetes of the young.European journal of human genetics : EJHG · 2014Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn women with hyperglycemia due to heterozygous glucokinase (GCK) mutations, the fetal genotype determines its growth. If the fetus inherits the mutation, birth weight is normal when maternal hyperglycemia is not treated, whereas intensive treatment may adversely reduce fetal growth. However, fetal genotype is not usually known antenatally, making treatment decisions difficult. HISTORY AND EXAMINATION: We report two women with gestational diabetes mellitus resulting from GCK mutations with hyperglycemia sufficient to merit treatment. INVESTIGATION: In both women, DNA from chorionic villus sampling, performed after high-risk aneuploidy screening, showed the fetus had inherited the GCK mutation. Therefore, maternal hyperglycemia was not treated. Both offspring had a normal birth weight and no peripartum complications.
conclusionsIn pregnancies where the mother has hyperglycemia due to a GCK mutation, knowing the fetal GCK genotype guides the management of maternal hyperglycemia. Fetal genotyping should be performed when fetal DNA is available from invasive prenatal diagnostic testing.
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