ArticleApplied and environmental microbiology2012
Mercury resistance and mercuric reductase activities and expression among chemotrophic thermophilic Aquificae.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
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- An implication of biotransformation in detoxification of mercury contamination by Morganella sp. strain IITISM23.Environmental science and pollution research international · 2021Article
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- Identification of a TeO32- reductase/mycothione reductase from Rhodococcus erythropolis PR4.FEMS microbiology ecology · 2020Article
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- Mercury detoxification by absorption, mercuric ion reductase, and exopolysaccharides: a comprehensive study.Environmental science and pollution research international · 2020Review
- Metalloid Reductase Activity Modified by a Fused SeACS chemical biology · 2020Article
- Mercury-TolerantFrontiers in plant science · 2020Article
- Life in High Salt Concentrations with Changing Environmental Conditions: Insights from Genomic and Phenotypic Analysis ofMicroorganisms · 2019Article
- Horizontal acquisition of hydrogen conversion ability and other habitat adaptations in the Hydrogenovibrio strains SP-41 and XCL-2.BMC genomics · 2019Article
- Molecular Adaptations of Bacterial Mercuric Reductase to the Hypersaline Kebrit Deep in the Red Sea.Applied and environmental microbiology · 2019Article
- Metalloid Reductase ofACS omega · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mercury (Hg) resistance (mer) by the reduction of mercuric to elemental Hg is broadly distributed among the Bacteria and Archaea and plays an important role in Hg detoxification and biogeochemical cycling. MerA is the protein subunit of the homodimeric mercuric reductase (MR) enzyme, the central function of the mer system. MerA sequences in the phylum Aquificae form the deepest-branching lineage in Bayesian phylogenetic reconstructions of all known MerA homologs. We therefore hypothesized that the merA homologs in two thermophilic Aquificae, Hydrogenobaculum sp. strain Y04AAS1 (AAS1) and Hydrogenivirga sp. strain 128-5-R1-1 (R1-1), specified Hg resistance. Results supported this hypothesis, because strains AAS1 and R1-1 (i) were resistant to >10 μM Hg(II), (ii) transformed Hg(II) to Hg(0) during cellular growth, and (iii) possessed Hg-dependent NAD(P)H oxidation activities in crude cell extracts that were optimal at temperatures corresponding with the strains' optimal growth temperatures, 55°C for AAS1 and 70°C for R1-1. While these characteristics all conformed with the mer system paradigm, expression of the Aquificae mer operons was not induced by exposure to Hg(II) as indicated by unity ratios of merA transcripts, normalized to gyrA transcripts for hydrogen-grown AAS1 cultures, and by similar MR specific activities in thiosulfate-grown cultures with and without Hg(II). The Hg(II)-independent expression of mer in the deepest-branching lineage of MerA from bacteria whose natural habitats are Hg-rich geothermal environments suggests that regulated expression of mer was a later innovation likely in environments where microorganisms were intermittently exposed to toxic concentrations of Hg.
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