Evidence map›Paper›PMID 22773606›Full record

ReviewHaematologica2012

Molecular pathogenesis of Waldenstrom's macroglobulinemia.

Esteban Braggio, Casey Philipsborn, Anne Novak, Lucy Hodge, Stephen Ansell, Rafael Fonseca

Open access · goldAbstract readReview
In one paragraph

Review in Haematologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Waldenström macroglobulinemia: biology, genetics, and therapy.Blood and lymphatic cancer : targets and therapy · 2016
    Review
  9. [Clinical and biological characteristics of non-IgM lymphoplasmacytic lymphoma].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2015
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Esteban BraggioDepartment of Hematology-Oncology, Mayo Clinic in Arizona, 13400 East Shea Boulevard, Collaborative Research Building, Room 1-105, Scottsdale, AZ 85259-5494, USA.
Casey Philipsborn
Anne Novak
Lucy Hodge
Stephen Ansell
Rafael Fonseca
Mayo Clinic in Arizona · USMidwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Waldenström's macroglobulinemia is an indolent, lymphoproliferative disease, characterized by a heterogeneous lymphoplasmacytic bone marrow infiltrate and high immunoglobulin M production. While technological advances over the past several decades have dramatically improved the possibilities of studying the molecular basis of Waldenström's macroglobulinemia, the pathogenesis of the disease remains fragmented. Undoubtedly, research has been successful in uncovering underlying aberrations and deregulated mechanisms in this disease, providing useful information for identifying biomarkers for disease diagnosis, risk stratification and therapeutic intervention, but there is still a long way to go before the pathogenesis of Waldenström's macroglobulinemia is fully revealed. In addition, the low number of in vitro or in vivo models significantly challenges extensive analysis. In this manuscript, we review the molecular basis of this disease.

Indexed as

HumansWaldenstrom Macroglobulinemia

Identifiers

PMID22773606
PMCPMC3436227
OpenAlexW2127335583

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.