Evidence map›Paper›PMID 22773602›Full record

Trial reportHaematologica2012

Atorvastatin reduces serum cholesterol and triglycerides with limited improvement in vascular function in adults with sickle cell anemia.

Candice Bereal-Williams, Roberto F Machado, Vicki McGowan, Amy Chi, Christian J Hunter, Gregory J Kato, Lori Hunter, Carole K Dalby, Kristine Partovi Hauser, Anitaben Tailor and 1 more

Open access · goldAbstract readClinical TrialLetter
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Haematologica, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Fatty Acid Induced Hypermethylation in theInternational journal of molecular sciences · 2023
    Article
  7. Review
  8. New insights into the pathophysiology and development of novel therapies for sickle cell disease.Hematology. American Society of Hematology. Education Program · 2018
    Review
  9. Evolving treatment paradigms in sickle cell disease.Hematology. American Society of Hematology. Education Program · 2017
    Review
  10. Article
  11. 2015 Clinical trials update in sickle cell anemia.American journal of hematology · 2015
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Candice Bereal-Williams
Roberto F Machado
Vicki McGowan
Amy Chi
Christian J Hunter
Gregory J Kato
Lori Hunter
Carole K Dalby
Kristine Partovi Hauser
Anitaben Tailor
Richard O Cannon
National Heart Lung and Blood Institute · USIllinois College · USNational Institutes of Health · US

Funding

Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell DiseaseZIAHL006023 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KATO, GREGORY · 2009 to 2013
$258k
Atorvastatin Therapy to Improve Endothelial Function in Sickle Cell DiseaseZ01CL008052 · CLC · CLINICAL CENTER · PI KATO, GREGORY J · 2003 to 2008
$0k
Intramural NIH HHS Z01 CL008052Intramural NIH HHS ZIA HL006023PHS HHS 1 ZIAHL006023-03
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAnemia, Sickle CellAnticholesteremic AgentsAtorvastatinCholesterolCohort StudiesFemaleHeptanoic AcidsHumansHypercholesterolemiaMaleMiddle AgedPyrrolesAnticholesteremic AgentsAtorvastatinCholesterolHeptanoic AcidsPyrroles

Identifiers

PMID22773602
PMCPMC3487454
OpenAlexW2040213541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.