Evidence map›Paper›PMID 22773557›Full record

ArticleStroke2012

Patients living in impoverished areas have more severe ischemic strokes.

Dawn Kleindorfer, Christopher Lindsell, Kathleen A Alwell, Charles J Moomaw, Daniel Woo, Matthew L Flaherty, Pooja Khatri, Opeolu Adeoye, Simona Ferioli, Brett M Kissela

Abstract read
In one paragraph

Article in Stroke, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dawn KleindorferDepartment of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. dawn.kleindorfer@uc.edu
Christopher Lindsell
Kathleen A Alwell
Charles J Moomaw
Daniel Woo
Matthew L Flaherty
Pooja Khatri
Opeolu Adeoye
Simona Ferioli
Brett M Kissela

Funding

STROKE INCIDENCE AND OUTCOME AMONG BLACKS AND WHITESR01NS030678 · NINDS · UNIVERSITY OF CINCINNATI · PI KISSELA, BRETT M, KLEINDORFER, DAWN O · 1993 to 2024
$26.7M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
Cerebrovascular Fellowship Training ProgramT32NS047996 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Stacie Demel · 2006 to 2026
$3.7M
The Effect of Socioeconomic Status on Outcome After StrokeK23NS049463 · NINDS · UNIVERSITY OF CINCINNATI · PI KLEINDORFER, DAWN O · 2006 to 2010
$857k
NCATS NIH HHS UL1 TR000077NINDS NIH HHS K23 NS049463NINDS NIH HHS K23NS049463NINDS NIH HHS R01 NS030678NINDS NIH HHS R0I NS30678NINDS NIH HHS T32 NS047996
6 · The paper itself

Abstract

background and purposeInitial stroke severity is one of the strongest predictors of eventual stroke outcome. However, predictors of initial stroke severity have not been well-described within a population. We hypothesized that poorer patients would have a higher initial stroke severity on presentation to medical attention.

methodsWe identified all cases of hospital-ascertained ischemic stroke occurring in 2005 within a biracial population of 1.3 million. "Community" socioecomic status was determined for each patient based on the percentage below poverty in the census tract in which the patient resided. Linear regression was used to model the effect of socioeconomic status on stroke severity. Models were adjusted for race, gender, age, prestroke disability, and history of medical comorbidities.

resultsThere were 1895 ischemic stroke events detected in 2005 included in this analysis; 22% were black, 52% were female, and the mean age was 71 years (range, 19-104). The median National Institutes of Health Stroke Scale was 3 (range, 0-40). The poorest community socioeconomic status was associated with a significantly increased initial National Institutes of Health Stroke Scale by 1.5 points (95% confidence interval, 0.5-2.6; P<0.001) compared with the richest category in the univariate analysis, which increased to 2.2 points after adjustment for demographics and comorbidities.

conclusionsWe found that increasing community poverty was associated with worse stroke severity at presentation, independent of other known factors associated with stroke outcomes. Socioeconomic status may impact stroke severity via medication compliance, access to care, and cultural factors, or may be a proxy measure for undiagnosed disease states.

Indexed as

Poverty AreasAdultAgedAge FactorsBlack or African AmericanBlack PeopleBrain IschemiaFemaleHumansKentuckyMaleMiddle AgedOhioPopulationPovertyRecurrence

Identifiers

PMID22773557
PMCPMC3432858

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.