ReviewThe journal of physiological sciences : JPS2012
Acidification of the synaptic cleft of cone photoreceptor terminal controls the amount of transmitter release, thereby forming the receptive field surround in the vertebrate retina.
Review in The journal of physiological sciences : JPS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Acid-sensing ion channels as sensors of brain metabolic state.Pflugers Archiv : European journal of physiology · 2026Review
- Neuromolecular responses in disrupted mutualistic cleaning interactions under future environmental conditions.BMC biology · 2023Article
- Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina.Science advances · 2022Article
- Computational modeling predicts ephemeral acidic microdomains in the glutamatergic synaptic cleft.Biophysical journal · 2021Article
- A new tool to sense pH changes at the neuromuscular junction synaptic cleft.Scientific reports · 2020Article
- Alkalinization of the Synaptic Cleft during Excitatory Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- Activation of retinal glial (Müller) cells by extracellular ATP induces pronounced increases in extracellular H+ flux.PloS one · 2018Article
- Versatile functional roles of horizontal cells in the retinal circuit.Scientific reports · 2017Article
- Chemogenetic Activation of ipRGCs Drives Changes in Dark-Adapted (Scotopic) Electroretinogram.Investigative ophthalmology & visual science · 2016Article
- Specialized synaptic pathway for chromatic signals beneath S-cone photoreceptors is common to human, Old and New World primates.Journal of the Optical Society of America. A, Optics, image science, and vision · 2014Article
- Fluorescent imaging reports an extracellular alkalinization induced by glutamatergic activation of isolated retinal horizontal cells.Journal of neurophysiology · 2014Article
- Imaging an optogenetic pH sensor reveals that protons mediate lateral inhibition in the retina.Nature neuroscience · 2014Article
- Emerging functions of pannexin 1 in the eye.Frontiers in cellular neuroscience · 2014Review
- Article
- Independent control of reciprocal and lateral inhibition at the axon terminal of retinal bipolar cells.The Journal of physiology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the vertebrate retina, feedback from horizontal cells (HCs) to cone photoreceptors plays a key role in the formation of the center-surround receptive field of retinal cells, which induces contrast enhancement of visual images. The mechanism underlying surround inhibition is not fully understood. In this review, we discuss this issue, focusing on our recent hypothesis that acidification of the synaptic cleft of the cone photoreceptor terminal causes this inhibition by modulating the Ca channel of the terminals. We present evidence that the acidification is caused by proton excretion from HCs by a vacuolar type H(+) pump. Recent publications supporting or opposing our hypothesis are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.