ArticleAmerican journal of perinatology2012
Cytokines and posthemorrhagic ventricular dilation in premature infants.
Article in American journal of perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- An Integrative Review of Cytokine/Chemokine Predictors of Neurodevelopment in Preterm Infants.Biological research for nursing · 2019Review
- Combined Analysis ofFrontiers in neurology · 2018Article
- Downregulation of Aquaporin-4 Protects Brain Against Hypoxia Ischemia via Anti-inflammatory Mechanism.Molecular neurobiology · 2017Article
- High-mobility group box-1 and receptor for advanced glycation end products in preterm infants with brain injury.World journal of pediatrics : WJP · 2017Article
- Role of selected cytokines in the etiopathogenesis of intraventricular hemorrhage in preterm newborns.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Review
- Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats.Journal of neuroinflammation · 2016Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveTo determine in extremely low-birth-weight infants if elevated blood interferon-γ (IFN-γ), interleukin (IL)-1β, IL-18, tumor necrosis factor-α (TNF-α), and transforming growth factor-β are associated with need for shunt following severe intraventricular hemorrhage (IVH) or with ventricular dilation following milder grades/no IVH. STUDY
designWhole blood cytokines were measured on postnatal days 1, 3, 7, 14, and 21. Maximum IVH grade in the first 28 days, and shunt surgery or ventricular dilation on subsequent ultrasound (28 days' to 36 weeks' postmenstrual age) were determined.
resultsOf 902 infants in the National Institute of Child Health and Human Development Neonatal Research Network Cytokine study who survived to 36 weeks or discharge, 3.1% had shunts. Of the 12% of infants with severe (grade III to IV) IVH, 26% had a shunt associated with elevated TNF-α. None of the infants without IVH (69%) or with grade I (12%) or II (7%) IVH received shunts, but 8.4% developed ventricular dilation, associated with lower IFN-γ and higher IL-18.
conclusionStatistically significant but clinically nondiscriminatory alterations in blood cytokines were noted in infants with severe IVH who received shunts and in those without severe IVH who developed ventricular dilation. Blood cytokines are likely associated with brain injury but may not be clinically useful as biomarkers for white matter damage.
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