SynthesisLung2012
Effect of continuous positive airway pressure on hemoglobin A(1c) in patients with obstructive sleep apnea: a systematic review and meta-analysis.
Synthesis in Lung, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Effects of continuous positive airway pressure therapy duration on patients with obstructive sleep apnoea and type 2 diabetes mellitus: a systematic review and meta-analysis.BMJ open respiratory research · 2026Pooled it
- Positive Airway Pressure and Metabolic Markers in Children With Obstructive Sleep Apnea.Respiratory care · 2024Pooled it
- Effects of continuous positive airway pressure therapy on glycaemic control, insulin sensitivity and body mass index in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2015Pooled it
- CPAP therapy for patients with sleep apnea and type 2 diabetes mellitus improves control of blood pressure.Sleep & breathing = Schlaf & Atmung · 2017Trial
- Nocturia and obstructive sleep apnoea.Nature reviews. Urology · 2024Review
- Risk of diabetes in patients with sleep apnea: comparison of surgery versus CPAP in a long-term follow-up study.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2023Article
- Long-Term Weight Change and Glycemic Control in Patients With Type 2 Diabetes Mellitus and Treated vs. Untreated Sleep-Disordered Breathing-Analysis From the DIAbetes COhoRtE.Frontiers in neurology · 2021Article
- Chronic intermittent hypoxia in obstructive sleep apnea: a narrative review from pathophysiological pathways to a precision clinical approach.Sleep & breathing = Schlaf & Atmung · 2020Review
- The Veterans Affairs Continuous Positive Airway Pressure Use and Diabetic Retinopathy Study.Optometry and vision science : official publication of the American Academy of Optometry · 2019Article
- What can blood biomarkers tell us about cardiovascular risk in obstructive sleep apnea?Sleep & breathing = Schlaf & Atmung · 2015Review
- Effects of continuous positive airway pressure treatment on glycaemic control and insulin sensitivity in patients with obstructive sleep apnoea and type 2 diabetes: a meta-analysis.Archives of medical science : AMS · 2014Review
- Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives.Pulmonary medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is little conclusive data regarding the effect of continuous positive airway pressure (CPAP) on glycated hemoglobin (HbA(1c)). An earlier meta-analysis included two randomized controlled trials (RCTs) and found no significant effect of CPAP on HbA(1c). The meta-analysis presented here was conducted to include all relevant observational studies and RCTs on the effect of CPAP on HbA(1c).
methodsWe searched the PubMed database for all studies published prior to March 2012 for trials of the effect of CPAP on HbA(1c). Data from observational studies and RCTs that met the inclusion criteria were extracted for pre- and post-treatment HbA(1c).
resultsA total of nine studies that included 151 subjects met the inclusion criteria. The duration of the studies ranged from 41 days to 6 months. The mean net change in the HbA(1c) was -0.06 % [95 % CI: -0.24, 0.12] (p = 0.5). Five of the nine studies, with a total of 112 subjects, comprised patients with diabetes mellitus (DM) type 2. The mean net change in HbA(1c) for the subjects with DM type 2 was 0.08 % [95 % CI: -0.26, 0.42] (p = 0.65). The mean net change in HbA(1c) for subjects with DM type 2 in studies that were at least 3 months in duration was 0.16 % [95 % CI: -0.26, 0.58] (p = 0.45).
conclusionsThis meta-analysis found that CPAP does not reduce HbA(1c) levels when used in the short term.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.