Evidence map›Paper›PMID 22773109›Full record

Trial reportCirculation. Heart failure2012

Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training.

Ann M Swank, John Horton, Jerome L Fleg, Gregg C Fonarow, Steven Keteyian, Lee Goldberg, Gene Wolfel, Eileen M Handberg, Dan Bensimhon, Marie-Christine Illiou and 7 more

3 registry-linked trialsAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Heart failure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 184 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 25 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05376748 unknown statusnot on this mapstarted 2022, after this paper: background citation

Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction Before and After Ablation of Atrial Fibrillation

TypeobservationalSponsorUniversity of VermontRan2022 to 2024Enrolled34ConditionsHeart Failure With Preserved Ejection Fraction, Atrial Fibrillation
NCT05816265 phase4terminatednot on this mapstarted 2024, after this paper: background citation

Effects of IV Iron Replacement on Exercise Capacity in Individuals With Heart Failure With Reduced Ejection Fraction and Iron Deficiency

TypeinterventionalSponsorRadha GopalanRan2024 to 2025Enrolled6ConditionsHeart Failure, Iron-deficiencyArmsIV Iron Infusion Group
NCT06551012 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Influence of Active Muscle Mass and Nitrate Supplementation on Fatigability in Individuals With Heart Failure

TypeinterventionalSponsorNewcastle UniversityRan2025 to 2027Enrolled28ConditionsHeart Failure With Reduced Ejection FractionArmsNitrate-rich beetroot juice, Beetroot juice with nitrate extracted
3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 25 syntheses or guidelines pooled it.

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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ann M SwankExercise Physiology Laboratory University of Louisville, Louisville, KY 40292, USA. swank@louisville.edu
John Horton
Jerome L Fleg
Gregg C Fonarow
Steven Keteyian
Lee Goldberg
Gene Wolfel
Eileen M Handberg
Dan Bensimhon
Marie-Christine Illiou
Marianne Vest
Greg Ewald
Gordon Blackburn
Eric Leifer
Lawton Cooper
William E Kraus
HF-ACTION Investigators

Funding

ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL063747 · NHLBI · DUKE UNIVERSITY · PI O'CONNOR, CHRISTOPHER M · 2002 to 2008
$24.8M
THERAPEUTIC EXERCISE FOR KNEE OSTEOARTHRITISP60AG010484 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI EITTINGER, WALTER H · 1991 to 2002
$3.1M
ACTION EQOL STUDYU01HL066461 · NHLBI · DUKE UNIVERSITY · PI SCHULMAN, KEVIN ALAN · 2002 to 2008
$2.7M
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL064250 · NHLBI · HENRY FORD HEALTH SYSTEM · PI KETEYIAN, STEVEN J · 2002 to 2007
$1.4M
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL064264 · NHLBI · WASHINGTON UNIVERSITY · PI EWALD, GREGORY A · 2002 to 2006
$1.0M
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL068973 · NHLBI · BOSTON MEDICAL CENTER · PI COLUCCI, WILSON S. · 2002 to 2007
$1.0M
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL066501 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI PINA, ILEANA L · 2002 to 2007
$973k
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL064257 · NHLBI · OREGON HEALTH AND SCIENCE UNIVERSITY · PI ALHARETHI, RAMI · 2002 to 2005
$773k
ACTION-A CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISEU01HL066494 · NHLBI · OHIO STATE UNIVERSITY · PI ABRAHAM, WILLIAM TOBER · 2002 to 2005
$766k
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL068980 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FONAROW, GREGG C · 2002 to 2006
$709k
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL066482 · NHLBI · EMORY UNIVERSITY · PI SMITH, ANDREW · 2002 to 2005
$643k
ACTION - A CHF Trial Investigating Outcomes of ExerciseU01HL064265 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI WOLFEL, EUGENE E. · 2002 to 2005
$566k
NHLBI NIH HHS 5U01HL063747NHLBI NIH HHS 5U01HL064250NHLBI NIH HHS 5U01HL064257NHLBI NIH HHS 5U01HL064264NHLBI NIH HHS 5U01HL064265NHLBI NIH HHS 5U01HL066461NHLBI NIH HHS 5U01HL066482NHLBI NIH HHS 5U01HL066494NHLBI NIH HHS 5U01HL066501NHLBI NIH HHS 5U01HL068973NHLBI NIH HHS 5U01HL068980NHLBI NIH HHS U01 HL063747NHLBI NIH HHS U01 HL064250NHLBI NIH HHS U01 HL064257NHLBI NIH HHS U01 HL064264NHLBI NIH HHS U01 HL064265NHLBI NIH HHS U01 HL066461NHLBI NIH HHS U01 HL066482NHLBI NIH HHS U01 HL066494NHLBI NIH HHS U01 HL066501NHLBI NIH HHS U01 HL068973NHLBI NIH HHS U01 HL068980NIA NIH HHS P60AG010484NIA NIH HHS R37AG118915
6 · The paper itself

Abstract

backgroundThe prognostic ability of a single measurement of peak oxygen uptake (VO(2)) is well established in patients with chronic heart failure. The relation between a change in peak VO(2) and clinical outcomes is not well defined. METHODS AND

resultsThis investigation determined whether an increase in peak VO(2) was associated with a lower risk of the primary end point of time to all-cause mortality or all-cause hospitalization and 3 secondary end points. In Heart Failure and a Controlled Trial to Investigate Outcomes of Exercise Training, an exercise training trial for patients with systolic heart failure, cardiopulmonary exercise tests were performed at baseline and ≈3 months later in 1620 participants. Median peak VO(2) in the combined sample increased from 15.0 (11.9-18.0 Q1-Q3) to 15.4 (12.3-18.7 Q1-Q3) mL·kg(-1)·min(-1). Every 6% increase in peak VO(2,) adjusted for other significant predictors, was associated with a 5% lower risk of the primary end point (hazard ratio=0.95; CI=0.93-0.98; P<0.001); a 4% lower risk of the secondary end point of time to cardiovascular mortality or cardiovascular hospitalization (hazard ratio=0.96; CI=0.94-0.99; P<0.001); an 8% lower risk of cardiovascular mortality or heart failure hospitalization (hazard ratio=0.92; CI=0.88-0.96; P<0.001); and a 7% lower all-cause mortality (hazard ratio=0.93; CI=0.90-0.97; P<0.001).

conclusionsAmong patients with chronic systolic heart failure, a modest increase in peak VO(2) over 3 months was associated with a more favorable outcome. Monitoring the change in peak VO(2) for such patients may have benefit in assessing prognosis.

Indexed as

Exercise TherapyExercise ToleranceOxygen ConsumptionAgedChronic DiseaseExercise TestFemaleHeart Failure, SystolicHospitalizationHumansMaleMiddle AgedPredictive Value of TestsProportional Hazards ModelsRecovery of FunctionRisk Assessment

Identifiers

PMID22773109
PMCPMC3732187

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.