Evidence map›Paper›PMID 22772897›Full record

ArticleCirculation. Arrhythmia and electrophysiology2012

Does location of epicardial adipose tissue correspond to endocardial high dominant frequency or complex fractionated atrial electrogram sites during atrial fibrillation?

Koichi Nagashima, Yasuo Okumura, Ichiro Watanabe, Toshiko Nakai, Kimie Ohkubo, Masayoshi Kofune, Hiroaki Mano, Kazumasa Sonoda, Takafumi Hiro, Mizuki Nikaido and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Comparative distribution of complex fractionated atrial electrograms, high dominant frequency (HDF) sites during atrial fibrillation and HDF sites during sinus rhythm.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2013
    Trial
  3. Article
  4. Article
  5. Review
  6. Article
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  8. Article
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  10. Article
  11. Role of epicardial adipose tissue in human atrial fibrillation.Journal of arrhythmia · 2023 · on this map
    Review
  12. Article
  13. Article
  14. Epicardial adipose tissue as a mediator of cardiac arrhythmias.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Cardiac Adiposity and Arrhythmias: The Role of Imaging.Diagnostics (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Koichi NagashimaDivision of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Yasuo Okumura
Ichiro Watanabe
Toshiko Nakai
Kimie Ohkubo
Masayoshi Kofune
Hiroaki Mano
Kazumasa Sonoda
Takafumi Hiro
Mizuki Nikaido
Atsushi Hirayama

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough increased epicardial adipose tissue (EAT) volume is known to be associated with increased prevalence of atrial fibrillation (AF), the exact mechanisms are unclear. Therefore, we investigated whether EAT locations were associated with high dominant frequency (DF) sites or complicated fractionated atrial electrogram sites during AF. METHODS AND

resultsThree-dimensional reconstruction computed tomography images depicting EAT volumes (obtained by 320-detector-row multislice computed tomography) were merged with NavX-based DF and complicated fractionated atrial electrogram maps obtained during AF for 16 patients with paroxysmal AF and for 18 patients with persistent AF. Agreement between locations of the EAT, especially EAT surrounding the left atrium, and of high DF or complicated fractionated atrial electrogram sites was quantified. In addition, serum biomarker levels were determined. EAT surrounding the left atrium volumes was significantly greater in patients with persistent AF than in patients with paroxysmal AF (52.9 cm(3) [95% CI, 44.2-61.5] versus 34.8 cm(3) [95% CI, 26.6-43.0]; P=0.007). Serum high-sensitivity C-reactive protein and interleukin-6 levels were significantly higher in persistent AF patients than in paroxysmal AF patients (median high-sensitivity C-reactive protein, 969 ng/mL [interquartile range, 307-1678] versus 320 ng/mL [interquartile range, 120-660]; P=0.008; median interleukin-6, 2.4 pg/mL [interquartile range, 1.7-3.2] versus 1.3 [interquartile range, 0.8-2.4] pg/mL; P=0.017). EAT locations were in excellent agreement with high DF sites (κ=0.77 [95% CI, 0.71-0.82]) but in poor agreement with complicated fractionated atrial electrogram sites (κ=0.22 [95% CI, 0.13-0.31]).

conclusionsIncreased EAT volume and elevation of inflammatory biomarkers are noted in persistent AF rather than paroxysmal AF patients. High DF sites are located adjacent to EAT sites. Thus, EAT may be involved in the maintenance of AF.

Indexed as

Electrophysiologic Techniques, CardiacAdipose TissueAdultAgedAtrial FibrillationBiomarkersC-Reactive ProteinEchocardiographyFemaleFourier AnalysisHeart AtriaHumansInflammation MediatorsInterleukin-6JapanLinear ModelsBiomarkersC-Reactive ProteinIL6 protein, humanInflammation MediatorsInterleukin-6Matrix Metalloproteinase 2MMP2 protein, human

Identifiers

PMID22772897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.