Evidence map›Paper›PMID 22772836›Full record

ArticleBriefings in bioinformatics2012

Ultrafast clustering algorithms for metagenomic sequence analysis.

Weizhong Li, Limin Fu, Beifang Niu, Sitao Wu, John Wooley

Abstract read
In one paragraph

Article in Briefings in bioinformatics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 215 papers.

0numbers the graph read from it
0cells of the map it votes in
215citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

215 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. ProbioticJournal of animal science and technology · 2026
    Article
  6. Article
  7. Exploring the protein universe with distant similarity detection methods.Protein science : a publication of the Protein Society · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. A Duplex qPCR Assay Targeting theInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Pike: OTU-Level Analysis for Oxford Nanopore Amplicon Metagenomics.International journal of molecular sciences · 2025
    Article
  19. Article
  20. Article

155 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Weizhong LiCenter for Research in Biological Systems, University of California San Diego, USA. liwz@sdsc.edu
Limin Fu
Beifang Niu
Sitao Wu
John Wooley

Funding

Novel Methods for Effective Analysis Assembly and Comparison of HMP SequencesR01HG005978 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, WEIZHONG · 2010 to 2012
$1.1M
CD-HIT: A Fast Program to Cluster and Compare Large Sets of Biological SequencesR01RR025030 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, WEIZHONG · 2008 to 2010
$1.0M
NCRR NIH HHS R01 RR025030NCRR NIH HHS R01RR025030NHGRI NIH HHS R01 HG005978NHGRI NIH HHS R01HG005978
6 · The paper itself

Abstract

The rapid advances of high-throughput sequencing technologies dramatically prompted metagenomic studies of microbial communities that exist at various environments. Fundamental questions in metagenomics include the identities, composition and dynamics of microbial populations and their functions and interactions. However, the massive quantity and the comprehensive complexity of these sequence data pose tremendous challenges in data analysis. These challenges include but are not limited to ever-increasing computational demand, biased sequence sampling, sequence errors, sequence artifacts and novel sequences. Sequence clustering methods can directly answer many of the fundamental questions by grouping similar sequences into families. In addition, clustering analysis also addresses the challenges in metagenomics. Thus, a large redundant data set can be represented with a small non-redundant set, where each cluster can be represented by a single entry or a consensus. Artifacts can be rapidly detected through clustering. Errors can be identified, filtered or corrected by using consensus from sequences within clusters.

Indexed as

AlgorithmsMetagenomeCluster AnalysisMetagenomicsSequence Analysis, DNA

Identifiers

PMID22772836
PMCPMC3504929

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.