ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
Association of coronary atherosclerotic burden with clinical presentation and prognosis in patients with stable and unstable coronary artery disease.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Bifurcation treatment with novel, highly flexible drug-eluting coronary stents in all-comers: 2-year outcome in patients of the DUTCH PEERS trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Trial
- Effect of Homoarginine on Coronary Artery Complexity and Atherosclerotic Burden in Patients with STEMI.Journal of clinical medicine · 2025Article
- Alterations of NMR-Based Lipoprotein Profile Distinguish Unstable Angina Patients with Different Severity of Coronary Lesions.Metabolites · 2023Article
- The relationship between the number of stenotic coronary arteries and the gut microbiome in coronary heart disease patients.Frontiers in cellular and infection microbiology · 2022Article
- Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease.Scientific reports · 2021Article
- Association between mean corpuscular volume and severity of coronary artery disease in the Northern Chinese population: a cross-sectional study.The Journal of international medical research · 2020Article
- Correlation of coronary artery calcium score and carotid artery intima-media thickness with severity of coronary artery disease.Journal of cardiovascular and thoracic research · 2020Article
- Plasma levels of receptor interacting protein kinase-3 correlated with coronary artery disease.Chinese medical journal · 2019Article
- Alterations in the gut microbiome and metabolism with coronary artery disease severity.Microbiome · 2019Article
- Association of coronary dominance with the severity of coronary artery disease: a cross-sectional study in Shaanxi Province, China.BMJ open · 2018Article
- Impact of income status on prognosis of acute coronary syndrome patients during Greek financial crisis.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Observational
- Gender differences in therapeutic recommendation after diagnostic coronary angiography: insights from the Coronary Angiography and PCI Registry of the German Society of Cardiology.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Detection of coronary artery disease in postmenopausal women: the significance of integrated stress imaging tests in a 4-year prognostic study.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Article
- Article
- Comparison of modification of diet in renal disease and chronic kidney disease epidemiology collaboration formulas in predicting long-term outcomes in patients undergoing stent implantation due to stable coronary artery disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Short-term outcome of patients with ST-segment elevation myocardial infarction (STEMI) treated with an everolimus-eluting bioresorbable vascular scaffold.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Observational
- Value of coronary artery calcium score to predict severity or complexity of coronary artery disease.Arquivos brasileiros de cardiologia · 2014Article
- Incidence and impact on prognosis of bleeding during percutaneous coronary interventions in patients with chronic kidney disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Clinical characteristics, morbidity, and prognostic value of concomitant coronary artery disease in idiopathic dilated cardiomyopathy.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Observational
- Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling.PloS one · 2013Article
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10 authors.
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Abstract
backgroundThe impact of coronary atherosclerotic burden on prognosis and presentation of patients with coronary artery disease (CAD) is unknown. We investigated the association of coronary atherosclerotic burden with clinical outcome and presentation as unstable angina in patients with CAD.
methodsThis study included 10,647 patients with stable (n = 8,149) and unstable (n = 2,498) CAD who underwent percutaneous coronary intervention (PCI). Coronary atherosclerotic burden was assessed by Gensini score. The primary outcome analysis was 1-year mortality.
resultsPatients were divided into groups according to quartiles of Gensini score: <13 (first quartile; n = 2,650 patients), 13 to <25 (second quartile; n = 2,611 patients), 25 to <53 (third quartile; n = 2,721 patients) and ≥ 53 (fourth quartile; n = 2,665 patients). There were 295 deaths during follow-up: 41 deaths in the first quartile, 42 deaths in the second quartile, 83 deaths in the third quartile and 129 deaths in the fourth quartile of Gensini score (Kaplan-Meier estimates of 1-year mortality 1.6, 1.7, 3.1 and 5.0 %, respectively; adjusted hazards ratio [HR] = 1.08, 95 % confidence interval [CI] 1.02-1.14, P = 0.007 for each 20-point increase in Gensini score). Gensini score was an independent correlate of presentation as unstable angina (adjusted odds ratio [OR] = 1.07, 95 % CI 1.05-1.10, P < 0.001, for each 20-point increase in the score). Coronary stenoses with ≥ 75 % of lumen obstruction mediated almost all the increased risk related to the atherosclerotic burden for presentation as unstable CAD (adjusted OR = 1.08, 95 % CI 1.05-1.12, P < 0.001).
conclusionIn patients with CAD, coronary atherosclerotic burden is independently associated with increased risk of 1-year mortality and presentation as unstable angina.
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