ArticleNature materials2012
Label-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces.
Article in Nature materials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 143 citations in OpenAlex.
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- Label-free mass and size characterization of few-kDa biomolecules by hierarchical vision transformer augmented nanofluidic scattering microscopy.Nature communications · 2026Article
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- Nanoscale capacitance spectroscopy based on multifrequency electrostatic force microscopy.Beilstein journal of nanotechnology · 2025Article
- Dielectric Detection of Single Nanoparticles Using a Microwave Resonator Integrated with a Nanopore.ACS omega · 2024Article
- Recent progress on field-effect transistor-based biosensors: device perspective.Beilstein journal of nanotechnology · 2024Review
- Transparent Colloids of Detonation Nanodiamond: Physical, Chemical and Biological Properties.Materials (Basel, Switzerland) · 2023Review
- Dielectric Properties of Polymer Nanocomposite Interphases Using Electrostatic Force Microscopy and Machine Learning.ACS applied electronic materials · 2023Article
- Dielectric constant measurement sensitivity in electrostatic force and force gradient microscopy-based modes.Journal of applied physics · 2023Article
- Multifrequency dielectric mapping of fixed mice colon tissues in cell culture mediaFrontiers in bioengineering and biotechnology · 2023Article
- Magnetic Force Probe Characterizations of Nanoscaled Ferromagnetic Domains: Finite-Element Magnetostatic Simulations.Nanomaterials (Basel, Switzerland) · 2022Article
- Efficient long-range conduction in cable bacteria through nickel protein wires.Nature communications · 2021Article
- Dielectric properties and lamellarity of single liposomes measured by in-liquid scanning dielectric microscopy.Journal of nanobiotechnology · 2021Article
- Dielectric Imaging of Fixed HeLa Cells by In-Liquid Scanning Dielectric Force Volume Microscopy.Nanomaterials (Basel, Switzerland) · 2021Article
- Quantitative Assessment of the Physical Virus Titer and Purity by Ultrasensitive Flow Virometry.Angewandte Chemie (International ed. in English) · 2021Article
- Charge-polarized interfacial superlattices in marginally twisted hexagonal boron nitride.Nature communications · 2021Article
- Characterizing Dielectric Permittivity of Nanoscale Dielectric Films by Electrostatic Micro-Probe Technology: Finite Element Simulations.Sensors (Basel, Switzerland) · 2019Article
- Sizing single nanoscale objects from polarization forces.Scientific reports · 2019Article
- Direct study of the electrical properties of PC12 cells and hippocampal neurons by EFM and KPFM.Nanoscale advances · 2019Article
- Microwave measurement of giant unilamellar vesicles in aqueous solution.Scientific reports · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Label-free detection of the material composition of nanoparticles could be enabled by the quantification of the nanoparticles' inherent dielectric response to an applied electric field. However, the sensitivity of dielectric nanoscale objects to geometric and non-local effects makes the dielectric response extremely weak. Here we show that electrostatic force microscopy with sub-piconewton resolution can resolve the dielectric constants of single dielectric nanoparticles without the need for any reference material, as well as distinguish nanoparticles that have an identical surface but different inner composition. We unambiguously identified unlabelled ~10 nm nanoparticles of similar morphology but different low-polarizable materials, and discriminated empty from DNA-containing virus capsids. Our approach should make the in situ characterization of nanoscale dielectrics and biological macromolecules possible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.