ArticleThe Pediatric infectious disease journal2012
Clinical and demographic characteristics of seasonal influenza in pediatric patients with cancer.
Article in The Pediatric infectious disease journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.Influenza and other respiratory viruses · 2016Pooled it
- Boosting the influenza vaccine schedule in children with cancer: a prospective open-label study.NPJ vaccines · 2025Article
- Seasonal Influenza in Children With Cancer.Cureus · 2024Review
- Exploring the impact of breast cancer on colonization resistance of mouse microbiota using network node manipulation.Heliyon · 2024Article
- Disease burden and high-risk populations for complications in patients with acute respiratory infections: a scoping review.Frontiers in medicine · 2024Article
- Combination of procalcitonin and C-reactive protein levels in the early diagnosis of bacterial co-infections in children with H1N1 influenza.Influenza and other respiratory viruses · 2019Article
- Vaccination against influenza at a European pediatric cancer center: immunization rates and attitudes among staff, patients, and their families.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Article
- The Effectiveness of Trivalent Inactivated Influenza Vaccine in Children with Acute Leukemia.The Journal of pediatrics · 2017Observational
- Acute respiratory infections in children and adolescents with acute lymphoblastic leukemia.Cancer · 2016Article
- Immunogenicity and clinical effectiveness of the trivalent inactivated influenza vaccine in immunocompromised children undergoing treatment for cancer.Cancer medicine · 2016Article
- Burden of Influenza-Related Hospitalizations and Attributable Mortality in Pediatric Acute Lymphoblastic Leukemia.Journal of the Pediatric Infectious Diseases Society · 2015Article
- A Quality Improvement Initiative to Increase and Sustain Influenza Vaccination Rates in Pediatric Oncology and Stem Cell Transplant Patients.Pediatric quality & safetyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundChanges in oncology care and the diagnosis and management of influenza over the past several decades may have altered the epidemiology and outcomes of influenza in pediatric oncology patients.
methodsThe clinical features and outcomes of 102 pediatric patients undergoing cancer therapy during 107 episodes of influenza between January 2002 and April 2009 were retrospectively ascertained.
resultsMedian age at the time of influenza was 7.2 years (interquartile range: 3.8-11.2 years); 46% of patients were male. Nineteen patients (18%) were recipients of hematopoietic stem cell transplants. Patients' median absolute neutrophil and lymphocyte counts were 1300/μL (interquartile range: 500-2967/μL) and 360/μL (interquartile range: 180-836/μL), respectively. Twelve patients (11%) had coinfections with influenza and one or more other respiratory pathogens. Influenza prompted patients' hospitalization during 64% of episodes, and 75% received antiviral therapy. Complications occurred in 30% of infections and serious complications occurred in 7%. Three patients died, but no deaths were directly attributable to influenza. Most patients had delays in cancer therapy; the median delay was 5 days. Neutropenia, concurrent infection, increasing age and having received hematopoietic stem cell transplant increased the risk of serious complications.
conclusionsAdvances in the management of pediatric cancer and influenza have not altered the epidemiology and outcome of influenza in oncology patients. Clinical features identify subgroups of patients with influenza who are at risk of poor outcomes and those with a good prognosis.
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