ArticleArtificial DNA, PNA & XNA
PNA bearing 5-azidomethyluracil: a novel approach for solid and solution phase modification.
Article in Artificial DNA, PNA & XNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Synthesis and structure-activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown.RSC chemical biology · 2022Article
- Novel nicotinoid structures for covalent modification of wood: an environmentally friendly way for its protection against insects.RSC advances · 2020Article
- Article
- Fluorogenic PNA probes.Beilstein journal of organic chemistry · 2018Review
- Synthesis and Improved Cross-Linking Properties of C5-Modified Furan Bearing PNAs.Molecules (Basel, Switzerland) · 2017Article
- Pyrene-modified PNAs: Stacking interactions and selective excimer emission in PNA2DNA triplexes.Beilstein journal of organic chemistry · 2014Article
- A solid-phase CuAAC strategy for the synthesis of PNA containing nucleobase surrogates.Artificial DNA, PNA & XNAArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fmoc- and Boc-protected modified monomers bearing 5-azidomethyluracil nucleobase were synthesized. Four different solid-phase synthetic strategies were tested in order to evaluate the application of this series of monomers for the solid-phase synthesis of modified PNA. The azide was used as masked amine for the introduction of amide-linked functional groups, allowing the production of a library of compounds starting from a single modified monomer. The azide function was also exploited as reactive group for the modification of PNA in solution via azide-alkyne click cycloaddition.
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