Evidence map›Paper›PMID 22771986›Full record

ReviewTranscription

Rethinking the role of TFIIF in transcript initiation by RNA polymerase II.

Donal S Luse

Abstract readReview
In one paragraph

Review in Transcription. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. On the NF-Y regulome as in ENCODE (2019).PLoS computational biology · 2020
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α.The Journal of biological chemistry · 2016
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Donal S LuseLerner Research Institute, Cleveland, OH, USA. lused@ccf.org

Funding

CONTROL OF TRANSCRIPTION IN EUKARYOTIC CELLSR01GM029487 · NIGMS · UNIVERSITY OF CINCINNATI · PI LUSE, DONAL · 1985 to 2009
$2.7M
NIGMS NIH HHS GM 29487NIGMS NIH HHS R01 GM029487
6 · The paper itself

Abstract

TFIIF is considered to be a general transcription factor, based on the fact that it is essential for assembly of RNA polymerase II preinitiation complexes on fully double-stranded templates in vitro. Existing models assign various tasks to TFIIF during preinitiation complex formation and transcript initiation. Recent results do not support all aspects of those models but they do emphasize the significance of the interaction of TFIIF and TFIIB. Other recent findings raise the possibility that a fraction of RNA polymerase II transcription complex assembly proceeds through a pathway that is independent of TFIIF.

Indexed as

AnimalsEukaryotaHumansPhosphorylationRNA Polymerase IITranscription Factors, TFIITranscription Factor TFIIBTranscription Initiation, GeneticRNA Polymerase IITranscription Factors, TFIITranscription Factor TFIIBtranscription factor TFIIF

Identifiers

PMID22771986
PMCPMC3654762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.