ArticleAmerican journal of epidemiology2012
Biogeographic ancestry, self-identified race, and admixture-phenotype associations in the Heart SCORE Study.
Article in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Impaired LC-NE System-A Novel Molecular Mechanism Underlying Health Disparity and Increased Prevalence of Alzheimer's Disease Among African Americans.Diagnostics (Basel, Switzerland) · 2026Article
- A high-throughput screening method for selecting feature SNPs to evaluate breed diversity and infer ancestry.Genome research · 2025Article
- A critical examination of the relationship between cardiovascular health, cognition, and dementia risk.Journal of Alzheimer's disease : JAD · 2025Article
- Obstructive Sleep Apnea and Alzheimer's Disease Pathology: Is Sleep Architecture the Missing Key?Journal of Alzheimer's disease : JAD · 2024Review
- Multivariate statistical approach and machine learning for the evaluation of biogeographical ancestry inference in the forensic field.Scientific reports · 2022Article
- Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2018Article
- Comparison of Genetic and Self-Identified Ancestry in Modeling Intracerebral Hemorrhage Risk.Frontiers in neurology · 2018Article
- Circulating T-Cell Subsets, Monocytes, and Natural Killer Cells in Peripartum Cardiomyopathy: Results From the Multicenter IPAC Study.Journal of cardiac failure · 2018Article
- The role of race and ethnicity in sleep, circadian rhythms and cardiovascular health.Sleep medicine reviews · 2017Review
- The prevalence and distribution of the amyloidogenic transthyretin (TTR) V122I allele in Africa.Molecular genetics & genomic medicine · 2016Article
- Sex and Race Differences in the Relationship between Obesity and C-Reactive Protein.Ethnicity & disease · 2016Article
- The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies.Frontiers in genetics · 2016Article
- African Ancestry Is Associated with Higher Intraocular Pressure in Latinos.Ophthalmology · 2016Article
- Article
- The correlation between ancestry and color in two cities of Northeast Brazil with contrasting ethnic compositions.European journal of human genetics : EJHG · 2015Article
- Biogeographic Ancestry in the African Descent and Glaucoma Evaluation Study (ADAGES): Association With Corneal and Optic Nerve Structure.Investigative ophthalmology & visual science · 2015Article
- Do genetic modifiers of high-density lipoprotein cholesterol and triglyceride levels also modify their response to a lifestyle intervention in the setting of obesity and type-2 diabetes mellitus?: The Action for Health in Diabetes (Look AHEAD) study.Circulation. Cardiovascular genetics · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Large epidemiologic studies examining differences in cardiovascular disease (CVD) risk factor profiles between European Americans and African Americans have exclusively used self-identified race (SIR) to classify individuals. Recent genetic epidemiology studies of some CVD risk factors have suggested that biogeographic ancestry (BGA) may be a better predictor of CVD risk than SIR. This hypothesis was investigated in 464 African Americans and 771 European Americans enrolled in the Heart Strategies Concentrating on Risk Evaluation (Heart SCORE) Study in March and April 2010. Individual West African and European BGA were ascertained by means of a panel of 1,595 genetic ancestry informative markers. Individual BGA varied significantly among African Americans and to a lesser extent among European Americans. In the total cohort, BGA was not found to be a better predictor of CVD risk factors than SIR. Both measures predicted differences in the presence of the metabolic syndrome, waist circumference, triglycerides, body mass index, very low density lipoprotein cholesterol, lipoprotein A, and systolic and diastolic blood pressure between European Americans and African Americans. These results suggest that for most nongenetic cardiovascular epidemiology studies, SIR is sufficient for predicting CVD risk factor differences between European Americans and African Americans. However, higher body mass index and diastolic blood pressure were significantly associated with West African BGA among African Americans, suggesting that BGA should be considered in genetic cardiovascular epidemiology studies carried out among African Americans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.