ReviewBrain research2012
Novel model for the mechanisms of glutamate-dependent excitotoxicity: role of neuronal gap junctions.
Review in Brain research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Understanding the Role of ATP Release through Connexins Hemichannels during Neurulation.International journal of molecular sciences · 2023Article
- Alleviation of cognitive deficits in a rat model of glutamate-induced excitotoxicity, using an N-type voltage-gated calcium channel ligand, extracted fromFrontiers in molecular neuroscience · 2023Article
- Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.Neuroscience · 2021Review
- Article
- Response Variability in Transcranial Direct Current Stimulation: Why Sex Matters.Frontiers in psychiatry · 2020Article
- Neuronal Cell Death.Physiological reviews · 2018Review
- Nicotine protects rat hypoglossal motoneurons from excitotoxic death via downregulation of connexin 36.Cell death & disease · 2017Article
- Naotaifang extract treatment results in increased ferroportin expression in the hippocampus of rats subjected to cerebral ischemia.Molecular medicine reports · 2015Article
- Knockdown of STIM1 improves neuronal survival after traumatic neuronal injury through regulating mGluR1-dependent Ca(2+) signaling in mouse cortical neurons.Cellular and molecular neurobiology · 2015Article
- Erythropoietin: powerful protection of ischemic and post-ischemic brain.Experimental biology and medicine (Maywood, N.J.) · 2014Review
- Glutamate-mediated excitotoxicity in schizophrenia: a review.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
- Pallidal gap junctions-triggers of synchrony in Parkinson's disease?Movement disorders : official journal of the Movement Disorder Society · 2014Article
- Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Electrical synapses and their functional interactions with chemical synapses.Nature reviews. Neuroscience · 2014Review
- Delayed innocent bystander cell death following hypoxia in Caenorhabditis elegans.Cell death and differentiation · 2014Article
- Not all brains are created equal: the relevance of individual differences in responsiveness to transcranial electrical stimulation.Frontiers in systems neuroscience · 2014Review
- The effect of transcranial direct current stimulation: a role for cortical excitation/inhibition balance?Frontiers in human neuroscience · 2013Review
- Are vesicular neurotransmitter transporters potential treatment targets for temporal lobe epilepsy?Frontiers in cellular neuroscience · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
In the mammalian central nervous system (CNS), coupling of neurons by gap junctions (electrical synapses) increases during early post-natal development, then decreases, but increases in the mature CNS following neuronal injury, such as ischemia, traumatic brain injury and epilepsy. Glutamate-dependent neuronal death also occurs in the CNS during development and neuronal injury, i.e., at the time when neuronal gap junction coupling is increased. Here, we review our recent studies on the regulation of neuronal gap junction coupling by glutamate during development and injury and on the role of gap junctions in neuronal cell death. A novel model of the mechanisms of glutamate-dependent neuronal death is discussed, which includes neuronal gap junction coupling as a critical part of these mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.