ReviewThe Indian journal of medical research2012
Serological tests for the diagnosis of active tuberculosis: relevance for India.
Review in The Indian journal of medical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- A case for eliminating Widal testing for enteric fever, India.Bulletin of the World Health Organization · 2026Article
- Comprehensive Review of Genital Tuberculosis: Epidemiological Patterns, Causal Agents, Diagnostic Strategies, Symptomatology and Fertility Consequences.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Antibodies as key mediators of protection againstFrontiers in immunology · 2024Review
- Understanding the bacillary load and host interaction to design a point-of-care test to diagnose tuberculosis.Frontiers in tuberculosis · 2023Article
- Antibodies as clinical tools for tuberculosis.Frontiers in immunology · 2023Review
- Tuberculosis in the Female Genital Tract.Cureus · 2022Review
- Nontubercular mycobacterial cough.BMJ case reports · 2022Article
- Machine learning analysis of SERS fingerprinting for the rapid determination ofComputational and structural biotechnology journal · 2022Article
- Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care.Diagnostics (Basel, Switzerland) · 2021Review
- Article
- Tuberculosis in South Asia: a tide in the affairs of men.Multidisciplinary respiratory medicine · 2018Review
- Molecular Diagnosis of Tuberculosis.Chonnam medical journal · 2018Review
- Point-of-Care Blood Tests: Do Indian Villagers Have Cultural Objections?Frontiers in chemistry · 2018Article
- Genital tuberculosis in females.The Indian journal of medical research · 2017Review
- Performance of a lateral flow immunochromatography test for the rapid diagnosis of active tuberculosis in a large multicentre study in areas with different clinical settings and tuberculosis exposure levels.Journal of thoracic disease · 2016Article
- Laboratory Diagnosis of Central Nervous System Infection.Current infectious disease reports · 2016Review
- Head and Neck Tuberculosis: Scenario in a Tertiary Care Hospital of North Eastern India.Journal of clinical and diagnostic research : JCDR · 2016Article
- Laboratory Diagnostics Market in East Africa: A Survey of Test Types, Test Availability, and Test Prices in Kampala, Uganda.PloS one · 2015Article
- The Application of GeneXpert MTB/RIF for Smear-Negative TB Diagnosis as a Fee-Paying Service at a South Asian General Hospital.Tuberculosis research and treatment · 2015Article
- A multicenter clinical evaluation of Mycobacterium tuberculosis IgG/IgM antibody detection using the colloidal gold method.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Diagnostic tests for active tuberculosis (TB) based on the detection of antibodies (serological tests) have been commercially available for decades, although no international guidelines have recommended their use. An estimated 1.5 million serological TB tests, mainly enzyme-linked immunosorbent assays, are performed in India alone every year, mostly in the private sector. The cost of serological tests in India is conservatively estimated at US $15 million (`825 million) per year. Findings from systematic reviews on the diagnostic accuracy of serological tests for both pulmonary and extra-pulmonary TB suggest that these tests are inaccurate and imprecise. A cost-effectiveness modelling study suggests that, if used as a replacement test for sputum microscopy, serology would increase costs to the Indian TB control sector approximately 4-fold and result in fewer disability-adjusted life years averted and more false-positive diagnoses. After considering all available evidence, the World Health Organization issued a strong recommendation against the use of currently available commercial serological tests for the diagnosis of TB disease. The expanding evidence base continues to demonstrate that the harms/risks of serological tests far outweigh the benefits. Greater engagement of the private sector is needed to discontinue the use of serological tests and to replace these tests with WHO-endorsed new diagnostics in India. The recent ban on import or sale of TB serological tests by the Indian health ministry is a welcome step in the right direction.
Indexed as
Identifiers
22771604PMC3401705What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.