Evidence map›Paper›PMID 22771576›Full record

Trial reportContemporary clinical trials2012

A web-based screening and accrual strategy for a cancer prevention clinical trial in healthy smokers.

Arash Mohebati, Allison Knutson, Xi Kathy Zhou, Judith J Smith, Powel H Brown, Andrew J Dannenberg, Eva Szabo

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Contemporary clinical trials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers.Cancer prevention research (Philadelphia, Pa.) · 2013
    Trial
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Arash MohebatiDepartment of Surgery (Head and Neck Service), Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Allison Knutson
Xi Kathy Zhou
Judith J Smith
Powel H Brown
Andrew J Dannenberg
Eva Szabo
Cornell University · USCenter for Cancer Research · USMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · US

Funding

HEAD AND NECK TRAINING PROGRAM SURGICAL ONCOLOGYT32CA009685 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI FAGIN, JAMES A, WONG, RICHARD J · 1992 to 2022
$3.6M
PHASE I and II CLINICAL TRIALS OF CHEMOPREVENTIVE AGENTS-261035159-261035159N01CN035159 · CN · UNIVERSITY OF TEXAS M D ANDER · PI LIPPMAN, SCOTT M. · 2004 to 2006
–
Intramural NIH HHS Z99 CA999999NCI NIH HHS N01 CN035159NCI NIH HHS N01-CN-35159NCI NIH HHS T32 CA009685NCI NIH HHS T32 CA09685NCI NIH HHS Y99 CA999999
6 · The paper itself

Abstract

Screening and recruitment of qualified subjects for clinical trials is an essential component of translational research, and it can be quite challenging if the most efficient recruitment method is not utilized. In this report, we describe a successful web-based screening and accrual method used in a randomized prospective chemoprevention clinical trial with urinary biomarker endpoints. The targeted study population was a group of at-risk healthy current smokers with no evidence of lung disease. Craigslist was used as the sole recruitment modality for this study. All interested subjects were directed to a pre-screening website, in which subject questionnaire responses were linked to the study coordinator's secure e-mail account. Of the 429 initial inquiries, 189 individuals were initially eligible based on the questionnaire response. One hundred twenty-two people were telephone-screened, of whom 98 subjects were consented, 84 were randomized and 77 subjects completed the study successfully. Utilizing this single web-based advertising strategy, accrual for the trial was completed 7 months prior to the projected date. Craigslist is a cost effective and efficient web-based resource that can be utilized in accruing subjects to some chemoprevention trials.

Indexed as

InternetPatient SelectionSmokingAdolescentAdultAgedAnti-Inflammatory Agents, Non-SteroidalBiomarkersChemopreventionHumansMiddle AgedNeoplasmsRacial GroupsRandomized Controlled Trials as TopicRisk FactorsYoung AdultAnti-Inflammatory Agents, Non-SteroidalBiomarkers

Identifiers

PMID22771576
PMCPMC3460548
OpenAlexW2043236519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.