ReviewAgeing research reviews2013
Pharmacological lifespan extension of invertebrates.
Review in Ageing research reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- The ACE inhibitor captopril inhibits ACN-1 to control dauer formation and aging.Development (Cambridge, England) · 2024Article
- Review
- Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treatedProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Antiaging agents: safe interventions to slow aging and healthy life span extension.Natural products and bioprospecting · 2022Review
- The flavonoid corylin exhibits lifespan extension properties in mouse.Nature communications · 2022Article
- Bridging the Gap: A Geroscience Primer for Neuroscientists With Potential Collaborative Applications.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Review
- Environmentally friendly achiote seed extracts with higher δ-tocotrienol content have higher in vitro and in vivo antioxidant activity than the conventional extract.Journal of food science and technology · 2021Article
- Article
- Article
- Sulforaphane promotesAging · 2021Article
- Reproductive Aging inFrontiers in cell and developmental biology · 2021Review
- Drug Screening Implicates Chondroitin Sulfate as a Potential Longevity Pill.Frontiers in aging · 2021Review
- Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes.Scientific reports · 2020Article
- Gene expression-based drug repurposing to target aging.Aging cell · 2018Article
- Aspirin Derivative 5-(Bis(3-methylbut-2-enyl)amino)-2-hydroxybenzoic Acid Improves Thermotolerance via Stress Response Proteins inMolecules (Basel, Switzerland) · 2018Article
- Shorter lifetime of a soil invertebrate species when exposed to copper oxide nanoparticles in a full lifespan exposure test.Scientific reports · 2017Article
- Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans.PloS one · 2017Article
- Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks.BMC systems biology · 2016Article
- Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Chemical activation of a food deprivation signal extends lifespan.Aging cell · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
There is considerable interest in identifying small, drug-like compounds that slow aging in multiple species, particularly in mammals. Such compounds may prove to be useful in treating and retarding age-related disease in humans. Just as invertebrate models have been essential in helping us understand the genetic pathways that control aging, these model organisms are also proving valuable in discovering chemical compounds that influence longevity. The nematode Caenorhabditis elegans has numerous advantages for such studies including its short lifespan and has been exploited by a number of investigators to find compounds that impact aging. Here, we summarize the progress being made in identifying compounds that extend the lifespan of invertebrates, and introduce the challenges we face in translating this research into human therapies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.