ReviewNeuroscience and biobehavioral reviews2012
Exercise offers anxiolytic potential: a role for stress and brain noradrenergic-galaninergic mechanisms.
Review in Neuroscience and biobehavioral reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 117 citations in OpenAlex.
- Impact of exercise on older adults' mood is moderated by sleep and mediated by altered brain connectivity.Social cognitive and affective neuroscience · 2020Trial
- Methods for measuring neural activity during voluntary wheel running.Journal of neuroscience methods · 2026Article
- Article
- A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses.Nature neuroscience · 2025Article
- The association between weekend warrior physical activity pattern and anxiety: evidence from a U.S. population-based study.BMC psychiatry · 2025Article
- Oxidative Stress: A New Pathophysiological Pathway in Parkinson's Disease and a Potential Target of the Brain-Sport Crosstalk.Parkinson's disease · 2025Review
- Acute Exercise Improves Large-Scale Brain Network Segregation in Healthy Older Adults.Brain connectivity · 2024Article
- Exercise as Treatment for "Stress-Related" Mental Disorders.Current neuropharmacology · 2024Article
- A Study of Brain Function Characteristics of Service Members at High Risk for Accidents in the Military.Brain sciences · 2023Article
- Dramatic impacts on brain pathology, anxiety, and cognitive function in the knock-in APPAlzheimer's research & therapy · 2022Article
- Effects of treadmill exercise on anxiety-like behavior in association with changes in estrogen receptors ERα, ERβ and oxytocin of C57BL/6J female mice.IBRO neuroscience reports · 2021Article
- Co-released norepinephrine and galanin act on different timescales to promote stress-induced anxiety-like behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Effect of Acute Aerobic Exercise on Ocular Measures of Attention to Emotionally Expressive Faces.International journal of behavioral medicine · 2021Article
- A model of negative emotional contagion between male-female rat dyads: Effects of voluntary exercise on stress-induced behavior and BDNF-TrkB signaling.Physiology & behavior · 2021Article
- Inhibition of mTOR signaling by genetic removal of p70 S6 kinase 1 increases anxiety-like behavior in mice.Translational psychiatry · 2021Article
- Rat models for low and high adaptive response to exercise differ for stress-related memory and anxiety.Physiological reports · 2021Article
- Physical Activity and Natural Products and Minerals in the SARS-CoV-2 Pandemic: An Update.Annals of applied sport science · 2021Article
- Possible Neuroprotective Mechanisms of Physical Exercise in Neurodegeneration.International journal of molecular sciences · 2020Review
- Sex differences in resilience: Experiential factors and their mechanisms.The European journal of neuroscience · 2020Review
- Acute forced exercise increases Bdnf IV mRNA and reduces exploratory behavior in C57BL/6J mice.Genes, brain, and behavior · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Although physical activity reduces anxiety in humans, the neural basis for this response is unclear. Rodent models are essential to understand the mechanisms that underlie the benefits of exercise. However, it is controversial whether exercise exerts anxiolytic-like potential in rodents. Evidence is reviewed to evaluate the effects of wheel running, an experimental mode of exercise in rodents, on behavior in tests of anxiety and on norepinephrine and galanin systems in neural circuits that regulate stress. Stress is proposed to account for mixed behavioral findings in this literature. Indeed, running promotes an adaptive response to stress and alters anxiety-like behaviors in a manner dependent on stress. Running amplifies galanin expression in noradrenergic locus coeruleus (LC) and suppresses stress-induced activity of the LC and norepinephrine output in LC-target regions. Thus, enhanced galanin-mediated suppression of brain norepinephrine in runners is supported by current literature as a mechanism that may contribute to the stress-protective effects of exercise. These data support the use of rodents to study the emotional and neurobiological consequences of exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.