ArticleFertility and sterility2012
Does higher starting dose of FSH stimulation with letrozole improve fertility preservation outcomes in women with breast cancer?
Article in Fertility and sterility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation.Human reproduction (Oxford, England) · 2023Pooled it
- Fertility preservation for patients with cancer: American Society of Clinical Oncology clinical practice guideline update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Guideline
- Fertility Preservation During the COVID-19 Pandemic: Modified But Uncompromised.Women's health reports (New Rochelle, N.Y.) · 2022Article
- Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage.International journal of molecular sciences · 2021Review
- Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity.International journal of molecular sciences · 2020Review
- Does daily co administration of gonadotropins and letrozole during the ovarian stimulation improve IVF outcome for poor and sub optimal responders?Journal of ovarian research · 2020Article
- Comparison between Slow Freezing and Vitrification for Human Ovarian Tissue Cryopreservation and Xenotransplantation.International journal of molecular sciences · 2019Article
- Challenging iatrogenic menopause. Oncofertility programme in Poland - a single-centre experience.Przeglad menopauzalny = Menopause review · 2019Article
- Ovarian tissue cryopreservation and transplantation in patients with cancer.Obstetrics & gynecology science · 2018Review
- Exogenous reproductive hormone use in breast cancer survivors and previvors.Nature reviews. Clinical oncology · 2018Review
- Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?BMC cancer · 2018Review
- Responses to fertility treatment among patients with cancer: a retrospective cohort study.Fertility research and practice · 2018Article
- Fifteen year follow-up of embryos cryopreserved in cancer patients for fertility preservation.Journal of assisted reproduction and genetics · 2013Article
- Fertility preservation in women with cancer.Clinical and experimental reproductive medicine · 2012Article
- Letrozole Reduces Ovulatory Responsiveness in In Vitro-Grown Mouse Follicles.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveTo evaluate the efficacy of ovarian stimulation with higher doses of gonadotropins in fertility preservation (FP) cycles with the intention to maximize the likelihood of future pregnancies.
designRetrospective (secondary analysis).
settingAcademic medical centers. PATIENT(S): Low-dose (LD, 150 IU; n = 34) versus high-dose (HD, >150 IU; n = 117) FSH start in 151 patients with breast cancer (BCa) undergoing ovarian stimulation for embryo cryopreservation with letrozole (LE) before cancer treatment. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): FP cycle outcomes. RESULT(S): Mean total FSH dose (2,037 ± 679 IU vs. 1,128 ± 381 IU) and FSH level on trigger day (21.1 ± 8.9 vs. 10.6 ± 4.5 mIU/mL) were higher in the HD group, confirming the receipt of higher-dose FSH. There was no difference in other patient characteristics. Despite the larger number of follicles >17 mm in diameter in the HD group (5.0 ± 2.0 vs. 3.4 ± 1.4), neither peak E(2) (498.0 ± 377.5 vs. 397.9 ± 320.3), number of oocytes (13.3 ± 8.7 vs. 12.3 ± 8.0), nor number of embryos (6.3 ± 4.7 vs. 5.4 ± 3.8) were significantly different from the LD group. Of those undergoing frozen embryo transfer (ET), live birth rate (LBR)/ET trended higher in the LD (9/15) compared with HD (2/11) group, with 2.1 ± 0.8 vs. 1.9 ± 0.3 embryos transferred, respectively. CONCLUSION(S): Higher-dose FSH stimulation in LE cycles does not improve outcomes and may be associated with lower LBR. Our findings may support minimal stimulation in young noninfertile women with BCa.
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