Evidence map›Paper›PMID 22771005›Full record

ArticleJournal of autoimmunity2012

Criteria for environmentally associated autoimmune diseases.

Frederick W Miller, K Michael Pollard, Christine G Parks, Dori R Germolec, Patrick S C Leung, Carlo Selmi, Michael C Humble, Noel R Rose

Open access · greenAbstract read
In one paragraph

Article in Journal of autoimmunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Epigenetics in Non-tumor Immune-Mediated Skin Diseases.Molecular diagnosis & therapy · 2021
    Review
  13. Mechanisms of Environment-Induced Autoimmunity.Annual review of pharmacology and toxicology · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Mercury-induced inflammation and autoimmunity.Biochimica et biophysica acta. General subjects · 2019
    Review
  19. Review
  20. The microbiome in autoimmune diseases.Clinical and experimental immunology · 2019
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Frederick W MillerEnvironmental Autoimmunity Group, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health Clinical Research Center, Bethesda, MD 20892-1301, USA. millerf@mail.nih.gov
K Michael Pollard
Christine G Parks
Dori R Germolec
Patrick S C Leung
Carlo Selmi
Michael C Humble
Noel R Rose
National Institutes of Health · USUniversity of California, Davis · USJohns Hopkins University · USNational Institute of Environmental Health Sciences · USScripps Research Institute · US

Funding

Environmental/genetic Risk Factors and Pathogenesis of Autoimmune DiseaseZIAES101074 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, LISA · 2009 to 2025
$34.6M
Role of Daf in Systemic AutoimmunityR01ES014847 · NIEHS · SCRIPPS RESEARCH INSTITUTE, THE · PI POLLARD, KENNETH MICHAEL · 2008 to 2012
$1.9M
Intramural NIH HHS ZIA ES101074NIEHS NIH HHS R01 ES014847
6 · The paper itself

Abstract

Increasing evidence supports a role for the environment in the development of autoimmune diseases, as reviewed in the accompanying three papers from the National Institute of Environmental Health Sciences Expert Panel Workshop. An important unresolved issue, however, is the development of criteria for identifying autoimmune disease phenotypes for which the environment plays a causative role, herein referred to as environmentally associated autoimmune diseases. There are several different areas in which such criteria need to be developed, including: 1) identifying the necessary and sufficient data to define environmental risk factors for autoimmune diseases meeting current classification criteria; 2) establishing the existence of and criteria for new environmentally associated autoimmune disorders that do not meet current disease classification criteria; and 3) identifying in clinical practice specific environmental agents that induce autoimmune disease in individual patients. Here we discuss approaches that could be useful for developing criteria in these three areas, as well as factors that should be considered in evaluating the evidence for criteria that can distinguish individuals with such disorders from individuals without such disorders with high sensitivity and specificity. Current studies suggest that multiple lines of complementary evidence will be important and that in many cases there will be clinical, serologic, genetic, epigenetic, and/or other laboratory features that could be incorporated as criteria for environmentally associated autoimmune diseases to improve diagnosis and treatment and possibly allow for preventative strategies in the future.

Indexed as

Gene-Environment InteractionAutoimmune DiseasesCongresses as TopicEnvironmentEnvironmental ExposureEpigenesis, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansResearch DesignRisk Factors

Identifiers

PMID22771005
PMCPMC3468712
OpenAlexW2079766591

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.