ReviewPain2012
Virtual reality for persistent pain: a new direction for behavioral pain management.
Registry-linked trialAbstract readReview
In one paragraph
Review in Pain, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05253157 (Changes in Pain Interference and Severity After an Episode of Virtual Reality-augmented Remote Rehabilitative Care), which is not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Changes in Pain Interference and Severity After an Episode of Virtual Reality-augmented Remote Rehabilitative Care: a Pragmatic Exploratory Descriptive Trial
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroscience of Virtual Reality: From Virtual Exposure to Embodied Medicine.Cyberpsychology, behavior and social networking · 2019Pooled it
- Feasibility and Acceptability of Perioperative Application of Biofeedback-Based Virtual Reality vs Control for Pain and Anxiety in Children and Adolescents Undergoing Surgery: Pilot Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- The Effect of Immersive Virtual Reality on Anterograde Amnesia and Subjective Pain During Procedures: A Within-Subject Randomized Controlled Study.Anesthesia and analgesia · 2026Trial
- The effect of active video games on pain intensity, joint range of motion, and motor function in children with burns: a randomized clinical trial.BMC pediatrics · 2025Trial
- Sustained symptom reduction in complex regional pain syndrome with a novel home-based virtual reality program: a pilot study.Frontiers in neurology · 2025Trial
- Adding tactile feedback increases avatar ownership and makes virtual reality more effective at reducing pain in a randomized crossover study.Scientific reports · 2023Trial
- Virtual reality distraction induces hypoalgesia in patients with chronic low back pain: a randomized controlled trial.Journal of neuroengineering and rehabilitation · 2020Trial
- Feasibility and Safety of a Virtual Reality Dodgeball Intervention for Chronic Low Back Pain: A Randomized Clinical Trial.The journal of pain · 2016Trial
- The Impact of Virtual Reality on Chronic Pain.PloS one · 2016Trial
- Design considerations of a randomized clinical trial on a cognitive behavioural intervention using communication and information technologies for managing chronic low back pain.BMC musculoskeletal disorders · 2013Trial
- Application of Virtual Reality in Pain Management of Patients with Postherpetic Neuralgia: A Randomized Controlled Trial.Pain and therapy · 2026Article
- Virtual Reality-Based Pain Modulation in Subacute Musculoskeletal Injury: Functional Near-Infrared Spectroscopy Study of Neural and Behavioral Correlates.JMIR serious games · 2026Article
- A feasibility and acceptability of virtual reality as a pain relief measure post primary and revision total knee replacement surgery in a hospital setting: quasi-experimental study.BMC musculoskeletal disorders · 2026Article
- Virtual Reality to Improve Pain Management and Mental Health in Stroke Survivors With Chronic Pain: Study Protocol for a Feasibility Randomized Controlled Trial on Virtual Reality-Acceptance and Commitment Therapy.JMIR research protocols · 2026Article
- Context-dependent placebo hypoalgesia through observational learning: the role of empathy in immersive and non-immersive environments.NPJ digital medicine · 2026Article
- Functional brain connectivity correlates of pain relief during virtual reality exposure in cancer patients.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Article
- The Role of Virtual Reality in the Management of Irritable Bowel Syndrome.Current gastroenterology reports · 2024Review
- Global Scientific Trends in Virtual Reality for Pain Treatment From 2000 to 2022: Bibliometric Analysis.JMIR serious games · 2023Article
- The Management of Chronic Pain: Re-Centring Person-Centred Care.Journal of clinical medicine · 2023Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Francis J KeefeDepartment of Psychiatry and Behavioral Sciences, Duke Pain Prevention and Treatment Research Program, Duke University, Suite 340, 2200 W Main St., Durham, NC 27705, USA Department of Psychology and Neuroscience, Duke Pain Prevention and Treatment Research Program, Duke University, Suite 340, 2200 W Main St., Durham, NC 27705, USA Department of Computer Science and Engineering, University of Minnesota, 4-192 Keller Hall, 200 Union St. SE, Minneapolis, MN 55455, USA Department of Mechanical Engineering, University of Washington, Box 352142, Seattle, WA 98195, USA.
Dane A Huling
Michael J Coggins
Daniel F Keefe
Zachary M Rosenthal
Nathaniel R Herr
Hunter G Hoffman
Funding
Thermally-Triggered Intra-articular Drug Delivery for OAP01AR050245 · NIAMS · DUKE UNIVERSITY · PI GUILAK, FARSHID · 2003 to 2012
$11.5MOPTIMIZING THE CONTROL OF PAIN FROM SEVERE BURNSR01GM042725 · NIGMS · UNIVERSITY OF WASHINGTON · PI PATTERSON, DAVID R · 1990 to 2018
$7.5MKnee Arthroplasity Pain Coping Training (KAST Pain): A Randomized TrialUM1AR062800 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI RIDDLE, DANIEL L · 2012 to 2016
$5.2MControlling Pain After TraumaR01AR054115 · NIAMS · UNIVERSITY OF WASHINGTON · PI PATTERSON, DAVID R · 2007 to 2017
$4.6MCoping Skills Training for Arthritis: An Effectiveness TrialR01AR054626 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRODERICK, JOAN E · 2007 to 2011
$3.9MPain, Distress and Mammography Use in Breast Cancer PatientsR01CA131148 · NCI · DUKE UNIVERSITY · PI KEEFE, FRANCIS J. · 2009 to 2013
$2.3MSpousal Expression of Criticism/Hostility and Adjustment among Chronic Pain PatieR01NR010777 · NINR · RUSH UNIVERSITY MEDICAL CENTER · PI BURNS, JOHN W. · 2008 to 2011
$1.8MRandomized Controlled Trial Computer-Base Intervention to Augment Drug CounselingR01DA026454 · NIDA · DUKE UNIVERSITY · PI ROSENTHAL, M. ZACHARY · 2009 to 2013
$1.7MCoping Skills Training for Spinal Cord Stimulator PatientsR01NS053759 · NINDS · DUKE UNIVERSITY · PI PORTER, LAURA S · 2008 to 2011
$1.6MSelf System Therapy and Chronic Low Back PainR01NS046422 · NINDS · DUKE UNIVERSITY · PI KEEFE, FRANCIS J. · 2003 to 2006
$1.6MVirtual Reality Analgesia for Rehabilitation in ChildrenR21HD040954 · NICHD · UNIVERSITY OF WASHINGTON · PI SHARAR, SAM R · 2001 to 2003
$683kKnee Arthroplasty Cognitive Behavioral Intervention: The (KABIC) TrialR34AR056727 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI RIDDLE, DANIEL L · 2009 to 2009
$191kNCI NIH HHS R01 CA131148NIAMS NIH HHS 1R01AR054115-01A1NIAMS NIH HHS 1UM1AR062800NIAMS NIH HHS P01 AR050245NIAMS NIH HHS P01 AR50245NIAMS NIH HHS R01 AR054115NIAMS NIH HHS R01 AR054626NIAMS NIH HHS R34 AR056727NIAMS NIH HHS UM1 AR062800NICHD NIH HHS HD40954-01NICHD NIH HHS R21 HD040954NIDA NIH HHS R01 DA026454NIDA NIH HHS R01-DA-026454NIGMS NIH HHS R01 GM042725NIGMS NIH HHS R01GM042725-17A1NINDS NIH HHS R01 NS046422NINDS NIH HHS R01 NS053759NINR NIH HHS R01 NR010777
Abstract
PubMed holds no abstract for this paper.
Indexed as
Behavior TherapyChronic PainHumansPain ManagementVirtual Reality Exposure Therapy
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05253157ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.