Evidence map›Paper›PMID 22770731›Full record

ReviewCurrent opinion in cell biology2012

Cadherin recognition and adhesion.

Deborah Leckband, Sanjeevi Sivasankar

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Cadherin cis and trans interactions are mutually cooperative.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. Article
  11. Cadherin Extracellular Domain Clustering in the Absence ofThe journal of physical chemistry letters · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Deborah LeckbandDepartment of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. leckband@illinois.edu
Sanjeevi Sivasankar
Iowa State University · USUniversity of Illinois Urbana-Champaign · US

Funding

Cadherin Adhesion and MechanosensingR01GM097443 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LECKBAND, DEBORAH E · 2012 to 2016
$1.3M
Polarization and directed cell movements in engineered cellular environmentsR21HD059002 · NICHD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LECKBAND, DEBORAH E · 2009 to 2010
$406k
NICHD NIH HHS R21 HD059002NIGMS NIH HHS R01 GM097443
6 · The paper itself

Abstract

Classical cadherins are the principle adhesive proteins at cohesive intercellular junctions, and are essential proteins for morphogenesis and tissue homeostasis. Because subtype-dependent differences in cadherin adhesion are at the heart of cadherin functions, several structural and biophysical approaches have been used to elucidate relationships between cadherin structures, biophysical properties of cadherin bonds, and cadherin-dependent cell functions. Some experimental approaches appeared to provide conflicting views of the cadherin binding mechanism. However, recent structural and biophysical data, as well as computer simulations generated new insights into classical cadherin binding that increasingly reconcile diverse experimental findings. This review summarizes these recent findings, and highlights both the consistencies and remaining challenges needed to generate a comprehensive model of cadherin interactions that is consistent with all available experimental data.

Indexed as

AdhesivenessAnimalsBinding SitesCadherinsCell AdhesionComputer SimulationHumansModels, MolecularProtein BindingCadherins

Identifiers

PMID22770731
PMCPMC3479310
OpenAlexW2036845260

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.