ArticleThe Journal of cell biology1990
Comparative behavior of membrane protein-antibody complexes on motile fibroblasts: implications for a mechanism of capping.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Design principles for selective polarization of PAR proteins by cortical flows.The Journal of cell biology · 2023Article
- Patterning and polarization of cells by intracellular flows.Current opinion in cell biology · 2020Review
- Going with the Flow (or Not).Biophysical journal · 2019Article
- Review
- Front-to-rear membrane tension gradient in rapidly moving cells.Biophysical journal · 2015Article
- Surface aggregation patterns of LDL receptors near coated pits III: potential effects of combined retrograde membrane flow-diffusion and a polarized-insertion mechanism.Theoretical biology & medical modelling · 2014Article
- BAR domain proteins regulate Rho GTPase signaling.Small GTPases · 2014Review
- Forward transport of proteins in the plasma membrane of migrating cerebellar granule cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Dynamic Association between HIV-1 Gag and Membrane Domains.Molecular biology international · 2012Article
- Mechanical integration of actin and adhesion dynamics in cell migration.Annual review of cell and developmental biology · 2010Review
- The transmembrane protein CBP plays a role in transiently anchoring small clusters of Thy-1, a GPI-anchored protein, to the cytoskeleton.Journal of cell science · 2009Article
- Cross-talk between TLR4 and FcgammaReceptorIII (CD16) pathways.PLoS pathogens · 2009Article
- Transient anchorage of cross-linked glycosyl-phosphatidylinositol-anchored proteins depends on cholesterol, Src family kinases, caveolin, and phosphoinositides.The Journal of cell biology · 2006Article
- Role of the cytoplasmic domains of viral glycoproteins in antibody-induced cell surface mobility.Journal of virology · 1993Article
- Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans.The Journal of cell biology · 1993Article
- Comparison of actin and cell surface dynamics in motile fibroblasts.The Journal of cell biology · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A characteristic feature of fibroblast locomotory activity is the rearward transport across the leading lamella of various materials used to mark the cell surface. The two processes most frequently invoked as explanations for this transport phenomenon, called capping, are (a) retrograde membrane flow arising from directed membrane insertion and (b) rearward cortical cytoskeletal flow arising from cytoskeletal assembly and contraction. The retrograde lipid flow hypothesis, the most current form of the membrane flow scheme, makes explicit predictions about the movement of membrane proteins subjected to the postulated rearward lipid flow. Several of these predictions were tested by comparing the behavior of four membrane proteins, Pgp-1, Thy-1, H-2, and influenza HA0, identified by fluorescent antibodies. With the exception of Pgp-1, these proteins were uniformly distributed under nonaggregated conditions but were capped when aggregated into patches. In contrast, Pgp-1 was capped in similar time frames in both nonaggregated and aggregated states where the lateral diffusion coefficients were very different. Furthermore, the capping behavior of two tagged membrane proteins was markedly different yet both had similar diffusion coefficients. The results from these tests disprove the bulk membrane flow hypothesis and are at odds with explicit predictions of the retrograde lipid flow hypothesis for the mechanism of capping. This work, therefore, supports the alternative cytoskeletal-based mechanism for driving capping. Requirements for coupling cytoskeletal movement to membrane components are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.