Evidence map›Paper›PMID 22770688›Full record

ArticleMagnetic resonance imaging2012

Informatics methods to enable sharing of quantitative imaging research data.

Mia A Levy, John B Freymann, Justin S Kirby, Andriy Fedorov, Fiona M Fennessy, Steven A Eschrich, Anders E Berglund, David A Fenstermacher, Yongqiang Tan, Xiaotao Guo and 10 more

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Bibliometrics research on radiomics of lung cancer.Translational cancer research · 2021
    Article
  6. Article
  7. Article
  8. Development and clinical application of radiomics in lung cancer.Radiation oncology (London, England) · 2017
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mia A LevyDepartment of Biomedical Informatics and Medicine, Division of Hematology and Oncology, Vanderbilt University School of Medicine, Nashville, TN 37232-6838, USA. mia.levy@vanderbilt.edu
John B Freymann
Justin S Kirby
Andriy Fedorov
Fiona M Fennessy
Steven A Eschrich
Anders E Berglund
David A Fenstermacher
Yongqiang Tan
Xiaotao Guo
Thomas L Casavant
Bartley J Brown
Terry A Braun
Andre Dekker
Erik Roelofs
James M Mountz
Fernando Boada
Charles Laymon
Matt Oborski
Daniel L Rubin

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
Multidisciplinary Training in Image-Guided TherapyR25CA089017 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FENNESSY, FIONA · 2001 to 2017
$7.8M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
Computerized Quantitative Imaging Assessment of Tumor BurdenU01CA142555 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2010 to 2014
$2.9M
Quantitiative MRI of prostate cancer as a biomarker and guide for treatmentU01CA151261 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FENNESSY, FIONA · 2010 to 2014
$1.8M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS P30 CA076292NCI NIH HHS R25 CA089017NCI NIH HHS U01 CA142555NCI NIH HHS U01 CA143062NCI NIH HHS U01 CA151261PHS HHS 261200800001EPHS HHS PAR-11-150
6 · The paper itself

Abstract

introductionThe National Cancer Institute Quantitative Research Network (QIN) is a collaborative research network whose goal is to share data, algorithms and research tools to accelerate quantitative imaging research. A challenge is the variability in tools and analysis platforms used in quantitative imaging. Our goal was to understand the extent of this variation and to develop an approach to enable sharing data and to promote reuse of quantitative imaging data in the community.

methodsWe performed a survey of the current tools in use by the QIN member sites for representation and storage of their QIN research data including images, image meta-data and clinical data. We identified existing systems and standards for data sharing and their gaps for the QIN use case. We then proposed a system architecture to enable data sharing and collaborative experimentation within the QIN.

resultsThere are a variety of tools currently used by each QIN institution. We developed a general information system architecture to support the QIN goals. We also describe the remaining architecture gaps we are developing to enable members to share research images and image meta-data across the network.

conclusionsAs a research network, the QIN will stimulate quantitative imaging research by pooling data, algorithms and research tools. However, there are gaps in current functional requirements that will need to be met by future informatics development. Special attention must be given to the technical requirements needed to translate these methods into the clinical research workflow to enable validation and qualification of these novel imaging biomarkers.

Indexed as

AlgorithmsBiomedical ResearchDatabases, FactualDiagnostic ImagingHumansInformation DisseminationMedical InformaticsNeoplasmsProgram DevelopmentSoftwareUnited States

Identifiers

PMID22770688
PMCPMC3466343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.