ArticleThe Journal of cell biology1990
Effect of nocodazole on vesicular traffic to the apical and basolateral surfaces of polarized MDCK cells.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 170 citations in OpenAlex.
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- Colchicine Blocks Tubulin Heterodimer Recycling by Tubulin Cofactors TBCA, TBCB, and TBCE.Frontiers in cell and developmental biology · 2021Article
- Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Intracellular Colocalization of Influenza Viral RNA and Rab11A Is Dependent upon Microtubule Filaments.Journal of virology · 2017Article
- Membrane Transport across Polarized Epithelia.Cold Spring Harbor perspectives in biology · 2017Review
- Analysis of AQP4 trafficking vesicle dynamics using a high-content approach.Biophysical journal · 2013Article
- Determinants of pH-dependent modulation of translocation in dermonecrotic G-protein-deamidating toxins.Toxins · 2013Article
- Hepatocyte polarity.Comprehensive Physiology · 2013Review
- Altered transcription factor trafficking in oxidatively-stressed neuronal cells.Biochimica et biophysica acta · 2012Article
- Translocation of transfected GLUT2 to the apical membrane in rat intestinal IEC-6 cells.Digestive diseases and sciences · 2012Article
- Agonists that increase [Ca²⁺](i) halt the movement of acidic cytoplasmic vesicles in MDCK cells.The Journal of membrane biology · 2011Article
- Comparison of FcRn- and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy.Traffic (Copenhagen, Denmark) · 2010Article
- PH-domain-dependent selective transport of p75 by kinesin-3 family motors in non-polarized MDCK cells.Journal of cell science · 2010Article
- Single vesicle analysis of endocytic fission on microtubules in vitro.Traffic (Copenhagen, Denmark) · 2008Article
- Foamy virus capsid assembly occurs at a pericentriolar region through a cytoplasmic targeting/retention signal in Gag.Traffic (Copenhagen, Denmark) · 2006Article
- Golgi positioning: are we looking at the right MAP?The Journal of cell biology · 2005Review
- Cholesterol depletion induces PKA-mediated basolateral-to-apical transcytosis of the scavenger receptor class B type I in MDCK cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A polarized cell, to maintain distinct basolateral and apical membrane domains, must tightly regulate vesicular traffic terminating at either membrane domain. In this study we have examined the extent to which microtubules regulate such traffic in polarized cells. Using the polymeric immunoglobulin receptor expressed in polarized MDCK cells, we have examined the effects of nocodazole, a microtubule-disrupting agent, on three pathways that deliver proteins to the apical surface and two pathways that deliver proteins to the basolateral surface. The biosynthetic and transcytotic pathways to the apical surface are dramatically altered by nocodazole in that a portion of the protein traffic on each of these two pathways is misdirected to the basolateral surface. The apical recycling pathway is slowed in the presence of nocodazole but targeting is not disrupted. In contrast, the biosynthetic and recycling pathways to the basolateral surface are less affected by nocodazole and therefore appear to be more resistant to microtubule disruption.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.