ArticleCell stem cell2012
The germ cell determinant Blimp1 is not required for derivation of pluripotent stem cells.
Article in Cell stem cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Hydra at the Crossroads of Evolution: Insights into Cell-type Diversification, Regeneration, and Epigenetic Regulation.Results and problems in cell differentiation · 2026Review
- Germline stem cells in human.Signal transduction and targeted therapy · 2022Review
- BMP4 drives primed to naïve transition through PGC-like state.Nature communications · 2022Article
- Transition of inner cell mass to embryonic stem cells: mechanisms, facts, and hypotheses.Cellular and molecular life sciences : CMLS · 2019Review
- Recent advances in understanding intestinal stem cell regulation.F1000Research · 2019Review
- PRDM1/BLIMP1 is widely distributed to the nascent fetal-placental interface in the mouse gastrula.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Article
- Destabilization of pluripotency in the absence of Mad2l2.Cell cycle (Georgetown, Tex.) · 2015Article
- Expression patterns of prdm1 during chicken embryonic and germline development.Cell and tissue research · 2014Article
- The development of a malignant tumor is due to a desperate asexual self-cloning process in which cancer stem cells develop the ability to mimic the genetic program of germline cells.Intrinsically disordered proteins · 2014Article
- Lessons for inductive germline determination.Molecular reproduction and development · 2013Review
- Derivation of human embryonic stem cells using a post-inner cell mass intermediate.Nature protocols · 2013Article
- PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation.Biology · 2013Article
- The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation.Nature cell biology · 2013Article
- Small SSEA-4-positive cells from human ovarian cell cultures: related to embryonic stem cells and germinal lineage?Journal of ovarian research · 2013Article
- Isolation of small SSEA-4-positive putative stem cells from the ovarian surface epithelium of adult human ovaries by two different methods.BioMed research international · 2013Article
- Pluripotency takes off without Blimp1.Cell stem cell · 2012Article
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10 authors.
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Abstract
Blimp1 (Prdm1), the key determinant of primordial germ cells (PGCs), plays a combinatorial role with Prdm14 during PGC specification from postimplantation epiblast cells. They together initiate epigenetic reprogramming in early germ cells toward an underlying pluripotent state, which is equivalent to embryonic stem cells (ESCs). Whereas Prdm14 alone can promote reprogramming and is important for the propagation of the pluripotent state, it is not known whether Blimp1 is similarly involved. By using a genetic approach, we demonstrate that Blimp1 is dispensable for the derivation and maintenance of ESCs and postimplantation epiblast stem cells (epiSCs). Notably, Blimp1 is also dispensable for reprogramming epiSCs to ESCs. Thus, although Blimp1 is obligatory for PGC specification, it is not required for the reversion of epiSCs to ESCs and for their maintenance thereafter. This study suggests that reprogramming, including that of somatic cells to ESCs, may not entail an obligatory route through a Blimp1-positive PGC-like state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.